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Steroid showdown: can a higher dose speed up recovery after gallbladder surgery?

NCT ID NCT07469332

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two doses of dexamethasone (a steroid) given during gallbladder surgery to see which works better for reducing nausea, pain, and inflammation after the operation. About 135 adults having laparoscopic gallbladder removal will be randomly assigned to receive either a moderate or high dose of the drug. The goal is to find the best dose to help patients recover faster and feel better after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexamethasone
What this could lead to
If it works, this could show that a higher dose of dexamethasone improves recovery after gallbladder surgery better than a moderate dose.
What could go wrong
This is a small, early-stage trial with only 135 people, so results may not apply to everyone. Higher steroid doses also carry risks like infection or blood sugar changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 135 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 65 years * ASA physical status I-II * Scheduled for elective laparoscopic cholecystectomy * Undergoing general anesthesia * Ability to provide written informed consent Exclusion Criteria: * Patients younger than 18 years or older than 65 years * Known allergy to dexamethasone * ASA physical status III or higher * Surgical procedures lasting longer than 120 minutes * Emergency surgeries * Pregnant or breastfeeding patients * Patients with coagulopathy or receiving anticoagulant therapy * Known allergy to local anesthetics * Localized infection at the injection site * Inflammatory bowel disease * Autoimmune diseses * Chronic pain conditions * Ocular herpes simplex infection * Cushing's disease * Myasthenia gravis * Anticipated poor compliance with the study protocol * Vaccination within the last 14 days * Use of systemic glucocorticoids or immunosuppressive drugs * İmpaired renal function (GFR \< 30 mL/min) * Liver cirrhosis * Congestive heart failure * Peripheral nerve disorders * Elective laparoscopic cholecystectomy due to malignancy * Conversion to open surgery during the operation * Epilepsy * Body mass index (BMI) \> 30 kg/m²

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PONV Postoperative recovery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation

    Ankara, Çankaya, 06800, Turkey (Türkiye)

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