New combo aims to outperform chemo for tough lung cancer

NCT ID NCT06899126

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 3 times

Summary

This study tests a new combination of two drugs (trastuzumab deruxtecan and pembrolizumab) against standard chemotherapy plus pembrolizumab as a first treatment for people with advanced non-small cell lung cancer that has high levels of HER2 and low PD-L1. About 686 adults will take part. The goal is to see if the new combo helps people live longer without their cancer growing.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

'Henry Dynant' Hospital Center
RECRUITING

Athens, Greece
Alaska Oncology & Hematology, LLC
RECRUITING

Anchorage, Alaska, 99508, United States
All India Institute of Medical Sciences
RECRUITING

Bhubaneswar, 751019, India
Altnagelvin Area Hospital
RECRUITING

Londonderry, BT47 6SB, United Kingdom
Anhui Provincial Hospital
RECRUITING

Hefei, China
Asan Medical Center
RECRUITING

Seoul, South Korea
Assistance Publique-Hôpitaux de Marseille
RECRUITING

Marseille, 13915, France
Azienda Ospedaliera S.Giovanni Addolorata
RECRUITING

Roma, 00184, Italy
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi Irccs
RECRUITING

Bologna, Italy
Azienda Ospedaliero-Universitaria S.Luigi Gonzaga
RECRUITING

Orbassano, 10043, Italy
BRCR Global Plantation
RECRUITING

Plantation, Florida, 33321, United States
Bay Pines VA Healthcare System
RECRUITING

Bay Pines, Florida, 33744, United States
Beacon Hospital Sdn Bhd
RECRUITING

Petaling Jaya, Malaysia
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
Biocenter
RECRUITING

Concepción, Chile
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
RECRUITING

Santo André, 09060-870, Brazil
CHA Bundang Medical Center, CHA University
RECRUITING

Seongnam, 13496, South Korea
CHU Angers - Hôpital Larrey
RECRUITING

Angers, 49933, France
CHU Helora-Hospital de Mons
RECRUITING

Mons, Belgium
CINME - Centro De Investigaciones Metabolicas
RECRUITING

Buenos Aires, Argentina
CIONC-Centro Integrado de Oncologia de Curitiba
RECRUITING

Curitiba, 80810-050, Brazil
CRIO - Centro Regional Integrado de Oncologia
RECRUITING

Fortaleza, 60336-045, Brazil
California Research Institute
RECRUITING

Los Angeles, California, 90027, United States
Cancer Hospital of Shandong First Medical University
RECRUITING

Jinan, China
Carolina Cancer Research Center
RECRUITING

Wilson, North Carolina, 27893, United States
Centre Georges Francois Leclerc
RECRUITING

Dijon, 21079, France
Centre Hospitalier Intercommunal de Créteil
RECRUITING

Créteil, 94010, France
Centre Leon Berard
RECRUITING

Lyon, France
Centro Hospitalar do Porto, E.P.E. - Hospital de Santo António
RECRUITING

Porto, 4099-001, Portugal
Centro Paulista de Oncologia S A
RECRUITING

Vila Olímpia, Brazil
Centro Ricerche Cliniche di Verona s.r.l.
RECRUITING

Verona, Italy
Centro de Investigacion Clinica Bradford Hill
RECRUITING

Santiago, 8420383, Chile
Centro de Investigacion Pergamino SA
RECRUITING

Pergamino, Argentina
Centro de Investigaciones Medicas y Desarrollo LC SRL (LC Investigacion)
RECRUITING

Ciudad Autonoma Buenos Aires, 1113, Argentina
Centro de Oncologia de Precision
RECRUITING

Santiago, 7560908, Chile
Centro de Pesquisas Clinica Reichow
RECRUITING

Blumenau, 89010-340, Brazil
Centro de Tratamento Oncologico (CTO)
RECRUITING

Ribeirão Preto, 14026-596, Brazil
Centrul de Oncologie Sfantul Nectarie Craiova
RECRUITING

Craiova, 200347, Romania
Chang Gung Memorial Hospital,Linkou
RECRUITING

Taoyuan City, Taiwan
Charing Cross Hospital
RECRUITING

London, United Kingdom
Chi Mei Hospital, Liouying
RECRUITING

Tainan, Taiwan
China-Japan Friendship hospital
RECRUITING

Beijing, China
Chongqing University Cancer Hospital
RECRUITING

Chongqing, China
Chu Helora Hospital La Louvière Site Jolimont
RECRUITING

La Louvière, 7100, Belgium
Chu Nantes - Hăpital Guillaume Et Renă Laă Nnec
RECRUITING

Saint-Herblain, France
Chu de Liăge
RECRUITING

Liège, Belgium
Chulabhorn Hospital
RECRUITING

Laksi, Thailand
Chungbuk National University Hospital
RECRUITING

Cheongju-si, 28644, South Korea
Cleveland Clinic Florida - Weston
RECRUITING

Weston, Florida, 33331, United States
Clinica Redsalud Vitacura
RECRUITING

Santiago, Chile
Clinical Research Alliance
ACTIVE_NOT_RECRUITING

Westbury, New York, 11590, United States
Clinique Clementville
RECRUITING

Montpellier, 34070, France
Colentina Hospital
RECRUITING

Bucharest, Romania
Complejo Hospitalario Universitario Insular-Materno Infantil
RECRUITING

Las Palmas de Gran Canaria, 35016, Spain
Complejo Hospitalario Universitario de Santiago
RECRUITING

Santiago de Compostela, 15706, Spain
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02216, United States
Deenanath Mangeshkar Hospital and Research Centre
RECRUITING

Pune, 411004, India
Delta Health Care S.R.L
RECRUITING

Bucharest, 14142, Romania
Eastbourne District General Hospital
RECRUITING

Eastbourne, BN21 2UD, United Kingdom
Ehime University Hospital
RECRUITING

Toon-shi, 162-0821, Japan
FirstHealth Cancer Center
RECRUITING

Pinehurst, North Carolina, 28374, United States
Fondazione del Piemonte per l'Oncologia IRCCS Candiolo
RECRUITING

Candiolo, Italy
Fujita Health University Hospital
RECRUITING

Toyoake-shi, 470-1192, Japan
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
RECRUITING

Sao Jose Rio Preto, 15090-000, Brazil
Gabrail Cancer Center
RECRUITING

Canton, Ohio, 44718, United States
General Hospital Papageorgiou
RECRUITING

Thessaloniki, 57010, Greece
General Hospital of Athens of Chest Diseases "SOTIRIA"
RECRUITING

Athens, 11527, Greece
Gleneagles Hospital Hong Kong
RECRUITING

Wong Chuk Hang, Hong Kong
Gleneagles Hospital Penang
RECRUITING

Jalan Pangkor, 10050, Malaysia
Grand Hôpital de Charleroi-Les Viviers
RECRUITING

Gilly, 6060, Belgium
Gulhane Training and Research Hospital
RECRUITING

Ankara, 6010, Turkey (Türkiye)
Gyeongsang National University Hospital
RECRUITING

Jinju, South Korea
Hacettepe University Medical Faculty
RECRUITING

Ankara, 6100, Turkey (Türkiye)
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, 450003, China
Hirosaki University Hospital
RECRUITING

Hirosaki-shi, 036-8563, Japan
Holy Cross Hospital
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Hong Kong Integrated Oncology Centre
RECRUITING

Hong Kong, China
Hong Kong United Oncology Centre
RECRUITING

Jordan, China
Hope and Healing Cancer Services
RECRUITING

Hinsdale, Illinois, 60521, United States
Hopital Albert Calmette - CHU Lille
RECRUITING

Lille, France
Hopital Bichat - Claude Bernard
RECRUITING

Paris, 75018, France
Hopital Larrey
RECRUITING

Toulouse, 31059, France
Hospices Civils de Lyon
RECRUITING

Bron, 69677, France
Hospital CUF Porto
RECRUITING

Porto, 4100-180, Portugal
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universidad de Chile
RECRUITING

Santiago, 8380456, Chile
Hospital Clinico Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Ernesto Dornelles
RECRUITING

Porto Alegre, 90035-170, Brazil
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Italiano de Buenos Aires
RECRUITING

Buenos Aires, Argentina
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, Malaysia
Hospital Nossa Senhora Da Conceição
RECRUITING

Porto Alegre, Brazil
Hospital Provincial de Castellon
RECRUITING

Castellion, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, Spain
Hospital São Lucas da PUCRS
RECRUITING

Porto Alegre, 90619-000, Brazil
Hospital Tengku Ampuan Afzan
RECRUITING

Kuantan, Malaysia
Hospital Universitari Dexeus
RECRUITING

Barcelona, Spain
Hospital Universitari Vall d'Hebron - VHIO
RECRUITING

Barcelona, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Austral
RECRUITING

Pilar, Argentina
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, Spain
Hospital Universitario Clinico San Carlos
RECRUITING

Madrid, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Lucus Augusti
RECRUITING

Lugo, 27003, Spain
Hospital Universitario Nuestra Señora de Valme
RECRUITING

Seville, 41014, Spain
Hospital da Luz
RECRUITING

Lisbon, 1500-650, Portugal
Hospital das Clínicas FMRP-USP
RECRUITING

Ribeirão Preto, 14051-140, Brazil
Hospital de Cancer de Barretos - Fundacao Pio XII
RECRUITING

Barretos, 14784-400, Brazil
Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
Hospital of the University of Occupational and Environmental Health
RECRUITING

Kitakyushu-shi, Japan
Hubei Cancer Hospital
RECRUITING

Wuhan, 430079, China
Humanitas Istituto Clinico Catanese
RECRUITING

Misterbianco, 95045, Italy
Hunan Cancer Hospital
RECRUITING

Changsha, China
Hăpital Ambroise Pară
RECRUITING

Boulogne-Billancourt, France
Hăpital Foch
RECRUITING

Suresnes, France
Hăpital Privă Du Confluent
RECRUITING

Nantes, France
ICO l'Hospitalet - Hospital Duran i Reynals
RECRUITING

Barcelona, 8908, Spain
Icesp - Instituto Do Câncer Do Estado de São Paulo Octavio Frias de Oliveira
RECRUITING

São Paulo, Brazil
Institut Bergonié
RECRUITING

Bordeaux, France
Institut de Cancerologie de L'Ouest
RECRUITING

Saint-Herblain, France
Instituto Argentino de Diagnostico y Tratamiento
RECRUITING

Buenos Aires, Argentina
Instituto Dâor Pesquisa E Ensino - Rio de Janeiro
RECRUITING

Rio de Janeiro, Brazil
Instituto Medico de la Fundacion Estudios Clinicos
RECRUITING

Rosario, Argentina
Instituto San Marcos
RECRUITING

San Juan, Argentina
Instituto de Investigaciones Clinicas Cordoba S.A.
RECRUITING

Córdoba, 5000, Argentina
Instituto de Investigaciones Metabolicas (IDIM)
RECRUITING

Buenos Aires, Argentina
Instituto de Oncologia de Rosario
RECRUITING

Rosario, Argentina
Institutul Oncologic
RECRUITING

Cluj-Napoca, 400015, Romania
Institutul Regional de Oncologie Lasi
RECRUITING

Lasi, 700483, Romania
Interbalkan Hospital of Thessaloniki
RECRUITING

Thessaloniki, Greece
Istituto Nazionale Per La Ricerca Sul Cancro Di Genova
RECRUITING

Genova, Italy
Istituto Nazionale Tumori Regina Elena IRCCS
RECRUITING

Roma, Italy
Jiangsu Province Hospital
RECRUITING

Nanjing, China
Jilin Cancer Hospital
RECRUITING

Changchun, 130000, China
Kanagawa Cancer Center
RECRUITING

Yokohama, Japan
Kansai Medical University Hospital
RECRUITING

Hirakata-shi, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, Taiwan
Keijinkai Teine Keijinkai Hospital
RECRUITING

Sapporo, Japan
Klinikum Esslingen GmbH
RECRUITING

Esslingen am Neckar, 73730, Germany
Koo Foundation Sun Yat-Sen Cancer Center
RECRUITING

Taipei, Taiwan
Kurume University Hospital
RECRUITING

Kurume-shi, 810-0001, Japan
Liaoning Cancer Hospital & Institute
RECRUITING

Shenyang, China
Liga Norte-Rio-Grandense Contra o Câncer
RECRUITING

Natal, 59075-740, Brazil
Linyi Cancer Hospital
RECRUITING

Linyi, China
Logan Health Research
RECRUITING

Kalispell, Montana, 59901, United States
Los Angeles Cancer Network (LACN)
RECRUITING

Los Angeles, California, 91204, United States
Lumi Research
RECRUITING

Kingwood, Texas, 77339, United States
Lynn Cancer Institute Center
RECRUITING

Boca Raton, Florida, 33486, United States
Matsusaka Municipal Hospital
RECRUITING

Matsusaka-shi, Japan
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mazumdar Shaw Medical Center
RECRUITING

Bangalore, India
Medical Park Seyhan Hospital
RECRUITING

Adana, Turkey (Türkiye)
Medipol University Medical Faculty
RECRUITING

Istanbul, 34147, Turkey (Türkiye)
Memorial Healthcare International S R L
RECRUITING

Bucharest, Romania
Metropolitan Hospital
RECRUITING

Neo Faliro, 18547, Greece
Mid-Florida Hematology & Oncology Centers, P.A.
RECRUITING

Orange City, Florida, 33763, United States
NHO Kinki-Chuo Chest Medical Center
RECRUITING

Sakaishi, Japan
NHO Okayama Medical Center
RECRUITING

Okayama, 700-0815, Japan
Nanfang Hospital of Southern Medical University
RECRUITING

Guangzhou, China
Narayana Superspeciality Hospital
RECRUITING

Howrah, India
National Cancer Center
RECRUITING

Goyang-si, 10408, South Korea
National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, 277-8577, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, Taiwan
National Taiwan University Cancer Center
RECRUITING

Taipei, 106, Taiwan
National and Kapodistrian University of Athens (Nkua)-University General Hospital Attikon
RECRUITING

Athens, Greece
Nirmal Hospital Private Limited
RECRUITING

Surat, India
Nottingham University Hospitals City Campus
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Obras Sociais Irmã Dulce - Hospital Santo Antônio
RECRUITING

Salvador, 40.414-120, Brazil
Oncoclínicas Rio de Janeiro
RECRUITING

Rio de Janeiro, 20230-130, Brazil
Orange Coast Memorial Medical Center Fountain Valley
RECRUITING

Fountain Valley, California, 97208, United States
Orlandi Oncologia
RECRUITING

Santiago, 7500713, Chile
Osaka City General Hospital
RECRUITING

Osaka, 533-0033, Japan
Osaka International Cancer Institute
RECRUITING

Osaka, 541-0045, Japan
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Ospedale Santa Croce
RECRUITING

Fano, 61032, Italy
Phramongkutklao Hospital
RECRUITING

Bangkok, Thailand
Piedmont Cancer Institute OneOncology
RECRUITING

Atlanta, Georgia, 30318, United States
Presidio Ospedaliero Di Livorno
RECRUITING

Livorno, Italy
Providence Medical Foundation
RECRUITING

Santa Rosa, California, 95403, United States
Queen Elizabeth Hospital
RECRUITING

Hong Kong, Hong Kong
Rajavithi Hospital
RECRUITING

Rajathevee, Thailand
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
S.C R.T.C Radiology Therapeutic Center S.R.L
RECRUITING

Otopeni, Romania
Saiseikai Kumamoto Hospital
RECRUITING

Kumamoto, Japan
Saitama Medical University International Medical Center
RECRUITING

Hidaka-shi, Japan
Samsung Medical Center
RECRUITING

Seoul, South Korea
Sanatorio Britanico S.A.
RECRUITING

Rosario, 2000, Argentina
Sanatorio Parque S.A.
RECRUITING

Rosario, Argentina
Seoul National University Bundang Hospital
RECRUITING

Seongnam, 13620, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 3722, South Korea
Shanghai East Hospital
RECRUITING

Shanghai, China
Shanxi Provincial Cancer Hospital
RECRUITING

Taiyuan, China
Shizuoka Cancer Center
RECRUITING

Sunto-gun, Japan
Sichuan Cancer Hospital
RECRUITING

Chengdu, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, China
Siriraj Hospital
RECRUITING

Bangkok, 10700, Thailand
Songklanagarind Hospital
RECRUITING

Hat Yai, 90110, Thailand
Special Anticancer Hospital of Piraeus 'Metaxa'
RECRUITING

Piraeus, Greece
Spitalul Clinic Militar de Urgenta Dr. "Constantin Papilian" Cluj-Napoca
RECRUITING

Cluj-Napoca, 400132, Romania
Spitalul Municipal Ploiesti
RECRUITING

Ploieşti, Romania
St Luke's Hospital
RECRUITING

Panórama, 55236, Greece
St. Charles Health System
RECRUITING

Bend, Oregon, 97701, United States
St. Marianna University Hospital
RECRUITING

Kawasaki-shi, 220-0011, Japan
Summit Cancer Treatment Center
RECRUITING

Spokane, Washington, 99208, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, Taiwan
The Catholic University of Korea, St. Vincent's Hospital
RECRUITING

Suwon, 16247, South Korea
The Chinese University of Hong Kong
RECRUITING

Shatin, Hong Kong
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, China
The First Hospital of China Medical University
RECRUITING

Shenyang, 110001, China
The First Hospital of Jilin University
RECRUITING

Changchun, China
The Queens Medical Center
RECRUITING

Honolulu, Hawaii, 96813-2402, United States
The Second Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, China
The Second Hospital of Anhui Medical University
RECRUITING

Hefei, China
The Second People's Hospital of Neijiang
RECRUITING

Neijiang, China
The University of Hong Kong
RECRUITING

Hong Kong, Hong Kong
Tianjin Medical University General Hospital
RECRUITING

Tianjin, China
Toho University Omori Medical Center
RECRUITING

Ōta-ku, Japan
Tokyo Medical University Hospital
RECRUITING

Shinjuku-ku, 220-0004, Japan
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
RECRUITING

Wuhan, China
Tottori University Hospital
RECRUITING

Yonago-shi, Japan
Tri-Service General Hospital
RECRUITING

Taipei, Taiwan
Unidade Local de Saude de Santa Maria, E.P.E. - Hospital Pulido Valente
RECRUITING

Lisbon, Portugal
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, China
Universitaetsmedizin Mannheim
RECRUITING

Manheim, Germany
Universitatsmedizin Mainz
RECRUITING

Essen, 60590, Germany
University General Hospital of Larissa
RECRUITING

Larissa, Greece
University General Hospital of Patras
RECRUITING

Pátrai, Greece
University of Texas M. D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Universtitaetsklinikum Essen
RECRUITING

Nordrhein Westfalen, Germany
Vajira Hospital
RECRUITING

Dusit, 10300, Thailand
Wakayama Medical University Hospital
RECRUITING

Wakayama, Japan
West China Hospital, Sichuan University
RECRUITING

Chengdu, China
Wojewodzki Szpital Im. SW. Ojca Pio W Przemyslu
RECRUITING

Rzeszów, Poland
Xiangyang Central Hospital
RECRUITING

Xiangyang, China
Yenepoya Medical College Hospital
RECRUITING

Mangalore, India

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