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Allergy pill put to the test against endometriosis pain

NCT ID NCT07821320

Symptom relief Sponsor: Medical University of Vienna Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 15, 2026 · Last updated Sep 18, 2026 · Updated 2 times

Summary

Endometriosis causes chronic pelvic pain and painful periods, and current treatments do not work for everyone. Researchers are testing whether desloratadine, an antihistamine usually taken for allergies, can reduce pain and improve quality of life. The trial enrolls 60 women aged 18 to 50 with confirmed endometriosis who report a low quality-of-life score. Participants receive either desloratadine or a placebo for a set period, and researchers measure changes in quality of life and period pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
desloratadine, an antihistamine commonly used for allergies
What this could lead to
If it works, desloratadine could offer a non-hormonal option to ease period pain and improve daily life for people with endometriosis.
What could go wrong
This is an early Phase 2 trial with 60 participants, so any benefit may be small or may not hold up in larger studies. Desloratadine can cause drowsiness, dry mouth, and fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2027

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 18-50 * By imaging (sonography or MRI) or surgery last 10 years confirmed endometriosis * EHP-30 Score \> 40 Exclusion Criteria: * Subject is unable or unwilling to participate * History of malignant diseases * Current immunosuppressant treatment * History of allergies and/or usage of antihistaminic treatments * Postmenopausal women * Current hormonal treatment * Surgical treatment \<1year

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Conditions

The condition(s) this trial relates to.

disease Dysmenorrhea endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis Endometriosis (diagnosis) Endometriosis and dysmenorrhea Endometriosis associated pelvic pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical University of Vienna

    Vienna, 1090, Austria

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