Brain scans and decision games: new study aims to unlock Depression's secrets

NCT ID NCT05630963

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 26 times

Summary

This study looks at how a specific brain system (the nociceptin receptor) affects decision-making and stress in people with current or past major depression. Researchers will use brain scans (MRI and PET), blood and saliva tests, and computer tasks to understand these connections. The goal is to find better ways to predict and understand depressive symptoms. Participants must be right-handed, aged 18-45, and not on psychiatric medications for at least 2 weeks.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • McLean Hospital

    RECRUITING

    Belmont, Massachusetts, 02478, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.