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Dental X-Rays under the microscope: could they harm your cells?

NCT ID NCT07330401

Knowledge-focused Sponsor: Yaxin Wang Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether two common dental X-ray types, OPG and CBCT, cause damage to cells in the mouth. Researchers collected cheek cell samples from 60 people before and 10-12 days after X-ray exposure. They counted micronuclei, a sign of cell damage, to compare the effects of the two X-ray methods across different age groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists choose safer X-ray methods and reduce potential cell damage from dental imaging.
What could go wrong
This is a small, completed observational study with only 60 participants, so results may not apply to everyone. It measures cell changes, not actual health risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Oct 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 15-25 years and 40-50 years undergoing routine dental radiographic examination (OPG or CBCT), with follow-up buccal cell sampling for cytogenetic analysis.

Ages

15 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Underwent routine dental imaging using OPG or CBCT (no additional radiation for research purposes). Age 15-25 years or 40-50 years at the time of enrolment. Able and willing to provide written informed consent (or consent from a legal guardian for minors). Agreed to provide pre-exposure and follow-up buccal epithelial cell samples. Exclusion Criteria: History of systemic diseases, including but not limited to leukemia, lymphoma, rheumatic disorders, or diabetes mellitus. Prior exposure to head-and-neck radiotherapy, immunosuppressive drugs, or cytotoxic medications. Presence of active infectious diseases or acute/chronic inflammatory conditions at the time of enrolment. Clinically visible oral pathological lesions, including mucosal abnormalities, gingivitis, or periodontitis. Use of removable intra-oral prostheses or appliances (e.g., dentures, orthodontic appliances). Engagement in smoking, alcohol consumption, or betel-nut chewing. Diagnostic or therapeutic X-ray exposure within the preceding 3 months. Previous or current oral mucosal diseases, including oral lichen planus, recurrent aphthous stomatitis, oral candidiasis, HSV infection, leukoplakia, oropharyngeal carcinoma, mucous membrane pemphigoid, or pemphigus vulgaris. Presence of persistent local irritants, including ill-fitting dental prostheses, sharp teeth/restorations, chemical irritation (acidic foods, alcohol-based mouthwash), or recurrent thermal injury.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cytotoxicity Dental X-ray exposure Genotoxicity Ionizing radiation exposure

Contacts and locations

Locations

  • universiti Sains Malaysia hospital

    Kota Bharu, Kelantan, 25000, Malaysia

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