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Training the immune system to hunt down leftover liver cancer cells

NCT ID NCT06193733

Prevention Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This phase 2 trial tests whether a vaccine made from a patient's own dendritic cells — immune cells trained to recognize liver cancer — can prevent the cancer from returning after surgical removal of the tumor. About 74 adults with a high risk of recurrence will receive the vaccine as an add-on to standard care. The goal is to see if this personalized immunotherapy can improve disease-free survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a personalized dendritic cell vaccine made from the patient's own immune cells
What this could lead to
If successful, this approach could offer a way to reduce the high recurrence rate of liver cancer after surgery, potentially improving long-term survival.
What could go wrong
This is an early-phase trial with a small number of participants, so the vaccine may not prove effective. Side effects from immune activation are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 74 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2019

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The patients have curative liver resection for primary or recurrent HCCs which are diagnosed by pathological figures, and the risk nomogram scores of tumor recurrence are $\\ge 101$ \[Hepatitis, score 57; platelet $\< 100\\times10\^3$, score 72; multiple tumors, score 69; cirrhosis, score 62; microvascular invasion, score 100; total tumor volume $\> 43.3\\text{cm}\^3$, score 90\]. * Age ≧20 years old and sign informed consent. * BCLC stage A-C * Child-Pugh sore ≤ 6 * Percentage of lymphocytes in peripheral blood ≧12%. * Performance status ECOG ≦2 * AST and ALT ≦ 5x upper limit of normal. * Platelet ≥ 80000/mm3 * WBC ≥ 3000/uL * RBC ≥ 2.5x106/uL * eGFR ≥ 30ml/min/1.73m2 * The patients must be disease-free after liver resection, which is confirmed by dynamic CT or MRI within 14 days. * The participants must have early stage or intermediate stage of HCC and receive liver resections to remove the tumors completely. * The participants must agree to harvest and preserve tumor specimens during operation. Exclusion Criteria: * Subjected having other malignancies except HCC are excluded. * Uncontrolled or clinically significant cardiac diseases. * Positive for HIV. * Active bacterial of fungal infections. * Prior chemotherapy within one month. * Use of other investigational drugs within one month. * Subjects with systemic steroid treatment within 14 days. * Subjects in the status of immune deficiency. * Subjects in the status of autoimmune diseases. * Subjects with long-term use of immunosuppressive agents. * Subjects with checkpoint inhibitor immunotherapy within one month. * Subjects with local regional therapy within one month.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hepatocellular carcinoma

Contacts and locations

Locations

  • Chang Gung Medical Foundation

    Taiyuan, Taoyuan, 333, Taiwan

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