New hope for bladder cancer: experimental drug combo targets tough cases

NCT ID NCT07129993

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This study tests a new drug, datopotamab deruxtecan (Dato-DXd), combined with standard chemotherapy (carboplatin or cisplatin) in people with advanced bladder cancer that worsened after prior treatment with enfortumab vedotin and pembrolizumab. About 630 adults will be randomly assigned to receive either the new combination or a different chemotherapy combination (gemcitabine plus carboplatin or cisplatin). The goal is to see if the new combo shrinks tumors, delays cancer growth, and improves survival.

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Contacts and locations

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Study contacts

Contact

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Locations

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Fullerton, California, 92835, United States
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Glendale, California, 91204, United States
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La Jolla, California, 92093, United States
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Orange, California, 92868, United States
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San Francisco, California, 94158, United States
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Aurora, Colorado, 80012, United States
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Orange City, Florida, 32763, United States
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St. Petersburg, Florida, 33701, United States
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Tamarac, Florida, 62269, United States
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Atlanta, Georgia, 30342, United States
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Locust Grove, Georgia, 30248, United States
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Effingham, Illinois, 62401, United States
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Niles, Illinois, 60714, United States
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Peoria, Illinois, 61615, United States
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Largo, Maryland, 20774, United States
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Boston, Massachusetts, 02216, United States
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Grand Rapids, Michigan, 49546, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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New York, New York, 10029, United States
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Chapel Hill, North Carolina, 27514, United States
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Raleigh, North Carolina, 27610, United States
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Portland, Oregon, 97227, United States
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Monroeville, Pennsylvania, 15146, United States
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Philadelphia, Pennsylvania, 19107, United States
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Providence, Rhode Island, 02906, United States
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Myrtle Beach, South Carolina, 29572, United States
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Germantown, Tennessee, 38138, United States
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Memphis, Tennessee, 38120, United States
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Nashville, Tennessee, 37203, United States
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Austin, Texas, 33322, United States
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Dallas, Texas, 75246, United States
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Dallas, Texas, 75390, United States
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Charlottesville, Virginia, 22908, United States
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Norfolk, Virginia, 23502-1871, United States
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Spokane, Washington, 99208, United States
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Madison, Wisconsin, 53715, United States
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Graz, 8036, Austria
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Krems, Austria
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Linz, 4010, Austria
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Salzburg, 5020, Austria
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Vienna, Austria
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Beijing, 100142, China
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Chengdu, China
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Guangzhou, China
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Angers, 49055, France
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Bordeaux, 33075, France
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Brest, France
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Calais, France
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Cedex 10, France
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Créteil, France
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Grenoble, France
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La Chaussée-Saint-Victor, France
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La Roche-sur-Yon, France
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Le Mans, France
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Lyon, France
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Marseille, 13273, France
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Marseille, France
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Montpellier, France
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Nantes, France
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Nîmes, France
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Paris, France
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Paris, France
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Pierre-Bénite, 69310, France
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Poitiers, France
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Quint-Fonsegrives, France
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Reims, France
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Saint-Etienne, France
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Saint-Herblain, France
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Strasbourg, 67065, France
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Toulouse, France
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Vandœuvre-lès-Nancy, France
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Eisleben Lutherstadt, 06295, Germany
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Nürtingen, Germany
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Stuttgart, 70174, Germany
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Naples, Italy
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Roma, Italy
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Rozzano, Italy
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Bunkyō City, 113-8519, Japan
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Bunkyō City, Japan
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Fukuoka, 812-8582, Japan
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Fukuoka, Japan
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Hirosaki-shi, Japan
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Kanazawa, Japan
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Kawasaki, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, Japan
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Kyoto, 606-8507, Japan
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Nagoya, Japan
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Niigata, Japan
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Okayama, 700-8558, Japan
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Osaka, Japan
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Osakasayama-shi, 589-8511, Japan
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Sapporo, Japan
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Shinjuku-ku, Japan
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Toyama, Japan
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Tsukuba, 305-8576, Japan
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Ube-shi, 755-8505, Japan

Conditions

Explore the condition pages connected to this study.

BLADDER CANCER UROTHELIAL CANCER