New drug combo before prostate surgery shows promise in early trial
NCT ID NCT07450599
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking darolutamide (a hormone-blocking pill) plus standard hormone therapy for 12 or 24 weeks before prostate removal surgery can reduce or eliminate cancer in men with high-risk localized prostate cancer. About 250 men in China will be randomly assigned to one of two treatment durations. The main goal is to see how many men have no cancer or only minimal cancer left in the removed prostate. Participants will be followed for up to 2 years after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Darolutamide (oral tablets) plus goserelin acetate implant (ADT)
What this could lead to
If successful, this could show that a shorter or longer course of darolutamide plus ADT before surgery improves cancer clearance, potentially leading to better outcomes for men with high-risk localized prostate cancer.
What could go wrong
This is an early Phase 2 study with only 250 participants, so results may not apply to all patients. The treatment may cause side effects, and it's not yet known if it improves long-term survival or just pathological response.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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2nd affiliated Hos. Harbin Medical University
NOT_YET_RECRUITINGHarbin, Heilongjiang, 150086, China
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Cancer Hospital, Chinese Academy of Medical Sciences
RECRUITINGBeijing, Beijing Municipality, 100000, China
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China Medical University (CMU) - First Affiliated Hospital
NOT_YET_RECRUITINGShenyang, Liaoning, 110001, China
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Dongyang People's Hospital
NOT_YET_RECRUITINGJinhua, Zhejiang, 322199, China
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Fujian Medical University - The First Affiliated Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, 350005, China
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Huazhong University of Science and Technology - Tongji Medical College - Wuhan Union Hospital
NOT_YET_RECRUITINGWuhan, Hubei, 430022, China
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Jinhua Municipal Central Hospital-Oncology Department
NOT_YET_RECRUITINGJinhua, Zhejiang, 321000, China
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Kunming Medical University (KMU) - Second Affiliated Hospital
NOT_YET_RECRUITINGKunming, Yunnan, 650101, China
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Lanzhou University - The Second Hospital (The Second Clinical Medical College of Lanzhou University)
NOT_YET_RECRUITINGLanzhou, Gansu, 730030, China
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NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School
RECRUITINGNanjing, Jiangsu, 210008, China
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Nanchang University - The First Affiliated Hospital
NOT_YET_RECRUITINGNanchang, Jiangxi, 330006, China
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Nanfang Hospital, Southern Medical University
NOT_YET_RECRUITINGGuangzhou, Guangdong, 510515, China
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Peking University First Hospital - Oncology Department
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100034, China
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Qilu Hosp., Shandong Univ.
NOT_YET_RECRUITINGJinan, Shandong, 250012, China
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Shanghai General Hospital
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200080, China
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Shanghai Jiao Tong University School of Medicine (SJTUSM) - XinHua Hospital
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200092, China
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Sichuan Cancer Hospital-Urology Department
NOT_YET_RECRUITINGChengdu, Sichuan, 610041, China
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The 2nd Hospital of Hebei Medical University
NOT_YET_RECRUITINGShijiazhuang, Hebei, 050000, China
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The Second Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITINGHefei, Anhui, 230601, China
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The Second Hospital of Tianjin Medical University
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, 300211, China
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The first Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITINGGuangzhou, Guangdong, 510230, China
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Wuhan University - Renmin Hospital (Wuhan University People's Hospital/Hubei Provincial People's Hospital)
NOT_YET_RECRUITINGWuhan, Hubei, 430060, China
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Zhengzhou University - First Affiliated Hospital (Henan Medical University - First Affiliated Hospital)
NOT_YET_RECRUITINGZhengzhou, Henan, 450052, China