New cocktail of drugs takes on multiple myeloma
NCT ID NCT04108195
First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times
Summary
This early-stage trial tests combinations of the drug daratumumab with two newer bispecific antibodies (talquetamab and teclistamab), with or without pomalidomide, in 290 people with multiple myeloma. The main goal is to find safe doses and understand side effects. Participants must have had at least three prior treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- daratumumab, talquetamab, teclistamab, pomalidomide
- What this could lead to
- If successful, this could point toward a new combination treatment for multiple myeloma that is more effective than current options.
- What could go wrong
- This is an early Phase 1b study focused on safety and dosing, not yet on effectiveness. The combinations may cause serious side effects or fail to work better than existing therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2, Canada
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City of Hope National Medical Center
Duarte, California, 91010, United States
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City of Hope Orange County Lennar Foundation Cancer Center
Irvine, California, 92618, United States
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Clinica Univ. de Navarra
Pamplona, 31008, Spain
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Germans Trias I Pujol
Barcelona, 08916, Spain
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Hosp Clinic de Barcelona
Barcelona, 08036, Spain
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Hosp Clinico Univ de Salamanca
Salamanca, 37007, Spain
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Hosp Univ Fund Jimenez Diaz
Madrid, 28040, Spain
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Inst. Cat. Doncologia-H Duran I Reynals
Barcelona, 08908, Spain
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LUMC
Leiden, 2333ZA, Netherlands
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Levine Cancer Institute
Charlotte, North Carolina, 28204, United States
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Medical College Of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Mount Sinai Medical Center
New York, New York, 10029, United States
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The Blavatnik Family Chelsea Medical Center at Mount Sinai
New York, New York, 10011, United States
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Universitaetsklinikum Hamburg Eppendorf
Hamburg, 20246, Germany
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Universitaetsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitatsklinikum Freiburg
Freiburg im Breisgau, 79106, Germany
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Universitatsklinikum Wurzburg
Würzburg, 97080, Germany
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University Health Network UHN Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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VU Medisch Centrum
Amsterdam, 1081 HV, Netherlands
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Vanderbilt Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, 27157, United States
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