New quadruple therapy shows promise in battling multiple myeloma
NCT ID NCT03710603
First seen Feb 17, 2026 · Last updated Jun 02, 2026 · Updated 16 times
Summary
This phase 3 study compares a four-drug combination (daratumumab, bortezomib, lenalidomide, and dexamethasone) against the standard three-drug regimen in 709 adults aged 18-70 with newly diagnosed multiple myeloma who are eligible for high-dose therapy. The goal is to see if adding daratumumab improves how long patients live without their cancer worsening. Participants receive the drugs in cycles, and the study tracks progression-free survival and minimal residual disease negativity.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alfred Hospital
Melbourne, Australia
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Ankara University
Ankara, Turkey (Türkiye)
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Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - G.M. Lancisi - G. Salesi Di Ancona
Ancona, Italy
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CHRU Hôtel Dieu
Nantes, France
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Erasmus MC
Rotterdam, Netherlands
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Hospital Clinic I Provincial de Barcelona
Barcelona, Spain
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Kantonsspital St. Gallen
Sankt Gallen, Switzerland
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Odense University Hospital
Odense, Denmark
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Oslo University Hospital
Oslo, Norway
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Regional General Hospital Alexandra
Athens, Greece
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University Hospital Leuven
Leuven, Belgium
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University Hospital Ostrava
Ostrava, Czechia
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Uniwersytet Jagiellonski Collegium Medicum
Krakow, Poland
Conditions
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