Can a Triple-Drug combo help CF patients cough less and move more?

NCT ID NCT04969224

Completed Disease control Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a combination drug (elexacaftor/tezacaftor/ivacaftor) in 82 people with cystic fibrosis aged 12 and older. Researchers used wearable devices to measure how much the drug reduced coughing and increased physical activity over 12 weeks. The goal was to see if the treatment improves everyday life beyond standard lung function tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: elexacaftor/tezacaftor/ivacaftor (a combination pill)
What this could lead to: If successful, this could show that the drug helps people with cystic fibrosis cough less and be more active in daily life.
What could go wrong: This is a small, open-label study (no placebo), so results may not be definitive. The drug is already approved, but benefits on cough and activity are still being explored.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS

Contacts and locations

Locations

Alfred Hospital

Melbourne, VIC, Australia
Cliniques Universitaires de Bruxelles Hopital Erasme

Brussels, Belgium
Corporacio Sanitaria Parc Tauli - Sabadell Hospital Universitari

Sabadell, Spain
Hospital Universitari Vall d Hebron

Barcelona, Spain
Hospital Universitario 12 de Octubre

Madrid, Spain
Hospital Universitario Ramon y Cajal

Madrid, Spain
Institute for Respiratory Health

Nedlands, Australia
Mater Adult Hospital

South Brisbane, Australia
Queen Elizabeth II Health Sciences Center

Halifax, Canada
Queensland Children's Hospital

South Brisbane, Australia
Royal Adelaide Hospital

Adelaide, Australia
Telethon Kids Institute

Nedlands, Australia
The Prince Charles Hospital

Chermside, Australia
The Royal Children's Hospital

Parkville, VIC, Australia
Universitair Ziekenhuis Brussel - Campus Jette

Brussels, Belgium
Universitair Ziekenhuis Gent

Ghent, Belgium
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg

Leuven, Belgium
University of Alberta Hospital, Edmonton Clinic

Edmonton, Canada
University of Calgary Medical Clinic of the Foothills Medical Centre

Calgary, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.