Can a Triple-Drug combo help CF patients cough less and move more?
NCT ID NCT04969224
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested a combination drug (elexacaftor/tezacaftor/ivacaftor) in 82 people with cystic fibrosis aged 12 and older. Researchers used wearable devices to measure how much the drug reduced coughing and increased physical activity over 12 weeks. The goal was to see if the treatment improves everyday life beyond standard lung function tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
elexacaftor/tezacaftor/ivacaftor (a combination pill)
What this could lead to
If successful, this could show that the drug helps people with cystic fibrosis cough less and be more active in daily life.
What could go wrong
This is a small, open-label study (no placebo), so results may not be definitive. The drug is already approved, but benefits on cough and activity are still being explored.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alfred Hospital
Melbourne, VIC, Australia
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Cliniques Universitaires de Bruxelles Hopital Erasme
Brussels, Belgium
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Corporacio Sanitaria Parc Tauli - Sabadell Hospital Universitari
Sabadell, Spain
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Hospital Universitari Vall d Hebron
Barcelona, Spain
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Hospital Universitario 12 de Octubre
Madrid, Spain
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Hospital Universitario Ramon y Cajal
Madrid, Spain
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Institute for Respiratory Health
Nedlands, Australia
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Mater Adult Hospital
South Brisbane, Australia
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Queen Elizabeth II Health Sciences Center
Halifax, Canada
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Queensland Children's Hospital
South Brisbane, Australia
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Royal Adelaide Hospital
Adelaide, Australia
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Telethon Kids Institute
Nedlands, Australia
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The Prince Charles Hospital
Chermside, Australia
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The Royal Children's Hospital
Parkville, VIC, Australia
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Universitair Ziekenhuis Brussel - Campus Jette
Brussels, Belgium
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Universitair Ziekenhuis Gent
Ghent, Belgium
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Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
Leuven, Belgium
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University of Alberta Hospital, Edmonton Clinic
Edmonton, Canada
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University of Calgary Medical Clinic of the Foothills Medical Centre
Calgary, Canada