Could a cancer drug ease diabetes in kids with rare fat disease?

NCT ID NCT03936829

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether cyclophosphamide, a drug that calms the immune system, can reduce insulin needs in people with a rare condition that causes fat loss (lipodystrophy) and type 1 diabetes. Ten participants will receive the treatment, and researchers will measure how much insulin they need to keep blood sugar in a healthy range. The goal is to see if the drug can improve the body's response to insulin, not to cure the disease.

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Conditions

The condition(s) this trial relates to.

acquired lipodystrophy panniculitis and localized lipodystrophy type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Children's Hospital of Fudan University

    Shanghai, Shanghai Municipality, China