Could timed light therapy save more premature babies?
NCT ID NCT03927833
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways of using phototherapy (light treatment) for jaundice in extremely premature infants (under 750 grams or 27 weeks gestation). One group gets continuous light, the other gets timed cycles based on bilirubin levels. The main goal is to see if cycled phototherapy helps more babies survive to go home. The trial has enrolled 1,700 infants across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Phototherapy lights (device)
What this could lead to
If it works, this could lead to a safer, more effective way to treat jaundice in extremely premature babies, potentially improving survival.
What could go wrong
This is a large trial, but results are not yet published. The approach may not prove better than standard continuous phototherapy, and individual responses may vary.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brown University - Women and Infants Hospital of Rhode Island
Providence, Rhode Island, 02905, United States
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Case Western Reserve University, Rainbow Babies and Children's Hospital
Cleveland, Ohio, 44106, United States
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Cincinnati Children's Medical Center
Cincinnati, Ohio, 45267, United States
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Duke University
Durham, North Carolina, 27710, United States
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Emory University
Atlanta, Georgia, 30303, United States
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Northwestern Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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RTI International
Durham, North Carolina, 27705, United States
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Research Institute at Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Sharp Mary Birch Hospital for Women & Newborns
San Diego, California, 92123, United States
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Stanford University
Palo Alto, California, 94304, United States
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Univeristy of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Mississippi Medical Center - Children's of Mississippi
Jackson, Mississippi, 39216, United States
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University of New Mexico
Albuquerque, New Mexico, 87131, United States
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University of Rochester
Rochester, New York, 14642, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75235, United States
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University of Utah
Salt Lake City, Utah, 84108, United States