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Two imaging methods face off in Nerve-Zapping procedure for face pain

NCT ID NCT06620172

Symptom relief Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 22, 2026 · Last updated Sep 23, 2026 · Updated 1 time

Summary

Researchers compare two ways of guiding a procedure that uses heat to damage a nerve cluster and ease the severe facial pain of idiopathic trigeminal neuralgia. Adults with pain lasting at least six months that has not responded well to medication receive either CT-guided or fluoroscopy-guided radiofrequency thermocoagulation. The trial tracks pain scores, medication use, and side effects over six months to see whether one imaging method offers better relief or safety.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radiofrequency thermocoagulation of the trigeminal ganglion, guided by CT imaging or fluoroscopy
What this could lead to
If one imaging method proves better, doctors could choose the more precise guidance technique to deliver longer-lasting pain relief with fewer complications for people with trigeminal neuralgia.
What could go wrong
This is a small, single-center study of 68 people, so the results may not apply broadly. Radiofrequency thermocoagulation carries risks of facial numbness, weakness, or pain recurrence, and neither imaging method may clearly outperform the other.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

68 people

The number who actually took part.

Started

Nov 2024

Finished

Oct 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>18 years * Idiopathic trigeminal neuralgia (TN) based on the International Headache Society criteria * Pain for at least six months and a NRS score greater than 6 despite medical treatment * Able to provide informed consent. * Agree to follow the study procedures and attend follow-up visits. Exclusion Criteria: * Vascular compression of the trigeminal nerve by MRI and MRI angiography and the presence of secondary causes such as multiple sclerosis * Trigeminal autonomic cephalalgias accompanied by autonomic symptoms * Dental or temporomandibular joint pathologies * Previous interventional procedures or surgery for TN * Coagulopathy or use of antiaggregants and anticoagulants * Cardiac pacemaker * Renal-hepatic insufficiency * Diagnosis of psychiatric illness * Malignancy * Injection site or systemic infection * Current participation in another clinical trial that could interfere with the outcomes of this study.

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Conditions

The condition(s) this trial relates to.

agnosia trigeminal neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Trigeminal neuralgia Trigeminal neuralgia, idiopathic

Contacts and locations

Locations

  • Zagazig University, Faculty of Medicine

    Zagazig, Sharqia Province, 44519, Egypt

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