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Can creatine and weight training rebuild strength after head and neck cancer?

NCT ID NCT07838090

Symptom relief Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 24, 2026 · Last updated Sep 25, 2026 · Updated 1 time

Summary

Researchers are testing a 10-week resistance training program, with or without creatine monohydrate supplements, in adults who recently finished curative treatment for head and neck cancer. The trial aims to see if the program is feasible and safe, and whether it improves body composition, physical function, fatigue, and quality of life. About 30 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Creatine monohydrate supplement combined with a supervised resistance training program
What this could lead to
If it works, this could offer a low-cost way to help head and neck cancer survivors regain strength and reduce fatigue after treatment.
What could go wrong
This is a small pilot study of 30 people, so it may not show clear benefits or apply to all survivors. Creatine can cause stomach upset, and exercise may be challenging during recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 years or older. 2. Diagnosis of head and neck cancer (AJCC stages I-IV). 3. Completed curative-intent primary treatment, including surgery, radiation, chemotherapy, or combination treatment, within the past 1 to 3 months. 4. Clearance to engage in moderate-intensity exercise based on the American College of Sports Medicine (ACSM) Preparticipation Screening Guidelines. 5. Willingness and ability to participate in both in-person and/or virtual supervised exercise sessions. 6. Willingness to adhere to the supplementation regimen throughout the study. 7. English-speaking and able to understand study instructions and complete questionnaires. 8. Access to internet for remotely supervised exercise sessions. 9. Availability for the full 10-week intervention and post-intervention assessments. Exclusion Criteria: 1. Current participation in structured resistance training 2 or more days per week within the past 6 months. 2. Cognitive, psychiatric, or neurologic conditions that would impair ability to consent or adhere to study procedures. 3. Pre-existing renal impairment. 4. Current use of creatine supplements, defined as consistently taking creatine more than 2 days per week for the past 6 months.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms Motor Activity neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer survivorship Head and neck cancer Physical function Treatment-related muscle loss

How to take part

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  1. The places running it

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  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

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