New cocktail aims to outsmart lung cancer resistance

NCT ID NCT04655976

Ongoing Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This phase 2/3 trial is testing whether adding two immunotherapy drugs (cobolimab and dostarlimab) to standard chemotherapy (docetaxel) helps people with advanced non-small cell lung cancer live longer. The study includes about 758 participants whose cancer has worsened after prior treatments. Researchers are comparing the three-drug combo against two-drug and single-drug options to see which works best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cobolimab, dostarlimab, and docetaxel
What this could lead to: If successful, this combination could offer a new treatment option that extends survival for people with advanced lung cancer who have already tried standard therapies.
What could go wrong: This is still an experimental approach. The trial is large but results are not yet available, and the added benefit over existing treatments is uncertain. Side effects from combining multiple drugs may be significant.

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Conditions

The condition(s) this trial relates to.

lung cancer non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER (NON-SMALL CELL)

Contacts and locations

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Locations

GSK Investigational Site

Fountain Valley, California, 92708, United States
GSK Investigational Site

Walnut Creek, California, 94596, United States
GSK Investigational Site

Norwich, Connecticut, 06360, United States
GSK Investigational Site

Washington D.C., District of Columbia, 20422, United States
GSK Investigational Site

Honolulu, Hawaii, 96819, United States
GSK Investigational Site

Iowa City, Iowa, 52242, United States
GSK Investigational Site

Edgewood, Kentucky, 41017, United States
GSK Investigational Site

Las Vegas, Nevada, 89144, United States
GSK Investigational Site

Mineola, New York, 11501, United States
GSK Investigational Site

New York, New York, 10016, United States
GSK Investigational Site

White Plains, New York, 10601, United States
GSK Investigational Site

Pittsburgh, Pennsylvania, 15224, United States
GSK Investigational Site

Pittsburgh, Pennsylvania, 15232, United States
GSK Investigational Site

Sioux Falls, South Dakota, 57105, United States
GSK Investigational Site

Houston, Texas, 77030, United States
GSK Investigational Site

Fredericksburg, Virginia, 22408, United States
GSK Investigational Site

Tacoma, Washington, 98405, United States
GSK Investigational Site

Buenos Aires, C1426ABP, Argentina
GSK Investigational Site

Cipoletti Rio Negro, R8324CVE, Argentina
GSK Investigational Site

Ciudad Autonoma de Buenos Aire, 1425, Argentina
GSK Investigational Site

Florida, 1602, Argentina
GSK Investigational Site

La Rioja, F5300COE, Argentina
GSK Investigational Site

Pergamino, B2700CPM, Argentina
GSK Investigational Site

Rosario, S2000DBS, Argentina
GSK Investigational Site

Viedma, R8500ACE, Argentina
GSK Investigational Site

South Brisbane, Queensland, 4101, Australia
GSK Investigational Site

Ashford, South Australia, 5037, Australia
GSK Investigational Site

Hobart, Tasmania, 7000, Australia
GSK Investigational Site

Ballarat, Victoria, 3350, Australia
GSK Investigational Site

Melbourne, Victoria, 3004, Australia
GSK Investigational Site

Mount Waverley, Victoria, 3350, Australia
GSK Investigational Site

Aalst, 9300, Belgium
GSK Investigational Site

Hasselt, 3500, Belgium
GSK Investigational Site

Kortrijk, 8500, Belgium
GSK Investigational Site

Blumenau, 89010340, Brazil
GSK Investigational Site

Fortaleza, 60336-232, Brazil
GSK Investigational Site

Porto Alegre, 90610000, Brazil
GSK Investigational Site

Rio de Janeiro, 22061080, Brazil
GSK Investigational Site

Rio de Janeiro, 22250-905, Brazil
GSK Investigational Site

Salvador, 40170-110, Brazil
GSK Investigational Site

São Paulo, 04014-002, Brazil
GSK Investigational Site

Greater Sudbury, Ontario, P3E 5J1, Canada
GSK Investigational Site

Kingston, Ontario, K7L 2V7, Canada
GSK Investigational Site

Oshawa, Ontario, L1G 2B9, Canada
GSK Investigational Site

Greenfield Park, Quebec, J4V 2H1, Canada
GSK Investigational Site

Montreal, Quebec, H3T 1E2, Canada
GSK Investigational Site

Helsinki, 00180, Finland
GSK Investigational Site

Kuopio, 70210, Finland
GSK Investigational Site

Créteil, 94010, France
GSK Investigational Site

Grenoble, 38043, France
GSK Investigational Site

Marseille, 13009, France
GSK Investigational Site

Nice, 06189, France
GSK Investigational Site

Quimper, 29107, France
GSK Investigational Site

Rennes, 35033, France
GSK Investigational Site

Tours, 37044, France
GSK Investigational Site

Augsburg, 86156, Germany
GSK Investigational Site

Bad Berka, 99437, Germany
GSK Investigational Site

Berlin, 12200, Germany
GSK Investigational Site

Bonn, 53113, Germany
GSK Investigational Site

Cologne, 51109, Germany
GSK Investigational Site

Dresden, 01307, Germany
GSK Investigational Site

Essen, 45147, Germany
GSK Investigational Site

Frankfurt, 60488, Germany
GSK Investigational Site

Frankfurt, 60590, Germany
GSK Investigational Site

Halle, 06120, Germany
GSK Investigational Site

Heidelberg, 69126, Germany
GSK Investigational Site

Karlsruhe, 76137, Germany
GSK Investigational Site

München, 80336, Germany
GSK Investigational Site

München, 81925, Germany
GSK Investigational Site

Oldenburg, 26121, Germany
GSK Investigational Site

Athens, 115 27, Greece
GSK Investigational Site

Athens, 11526, Greece
GSK Investigational Site

Athens, 11528, Greece
GSK Investigational Site

Athens, 12462, Greece
GSK Investigational Site

Larissa, 41100, Greece
GSK Investigational Site

Pylaia Thessaloniki, 570 01, Greece
GSK Investigational Site

Rio Patras, 26504, Greece
GSK Investigational Site

Thessaloniki, 55236, Greece
GSK Investigational Site

Thessaloniki, 57010, Greece
GSK Investigational Site

Ancona, 60126, Italy
GSK Investigational Site

Avellino, 83100, Italy
GSK Investigational Site

Florence, 50134, Italy
GSK Investigational Site

Milan, 20132, Italy
GSK Investigational Site

Milan, 20133, Italy
GSK Investigational Site

Monza, 20900, Italy
GSK Investigational Site

Naples, 80131, Italy
GSK Investigational Site

Orbassano to, 10043, Italy
GSK Investigational Site

Perugia, 06156, Italy
GSK Investigational Site

Siena, 53100, Italy
GSK Investigational Site

Kyoto, 612-8555, Japan
GSK Investigational Site

Miyagi, 981-1293, Japan
GSK Investigational Site

Osaka, 591-8555, Japan
GSK Investigational Site

Yamaguchi, 755-0241, Japan
GSK Investigational Site

Guadajalara, 44280, Mexico
GSK Investigational Site

Mexico City, 03100, Mexico
GSK Investigational Site

Mexico City, 03810, Mexico
GSK Investigational Site

Mexico City, 06700, Mexico
GSK Investigational Site

Mexico City, CP 14080, Mexico
GSK Investigational Site

Monterrey, 64460, Mexico
GSK Investigational Site

Puebla Puebla, 72560, Mexico
GSK Investigational Site

Amersfoort, 3813 TZ, Netherlands
GSK Investigational Site

Enschede, 7512 KZ, Netherlands
GSK Investigational Site

Groningen, 9713 GZ, Netherlands
GSK Investigational Site

Harderwijk, 3844 DG, Netherlands
GSK Investigational Site

Nijmegen, 6525 GA, Netherlands
GSK Investigational Site

Utrecht, 3543 AZ, Netherlands
GSK Investigational Site

Zwolle, 8025 AB, Netherlands
GSK Investigational Site

Bydgoszcz, 85-796, Poland
GSK Investigational Site

Gdynia, 81-519, Poland
GSK Investigational Site

Lodz, 90-338, Poland
GSK Investigational Site

Olsztyn, 10-357, Poland
GSK Investigational Site

Piła, 64-920, Poland
GSK Investigational Site

Poznan, 60-693, Poland
GSK Investigational Site

Bucharest, 013812, Romania
GSK Investigational Site

Craiova, 200347, Romania
GSK Investigational Site

Craiova Dolj, 200385, Romania
GSK Investigational Site

Otopeni, 075100, Romania
GSK Investigational Site

Timișoara, 300239, Romania
GSK Investigational Site

Chelyabinsk, 454048, Russia
GSK Investigational Site

Moscow Region, 143423, Russia
GSK Investigational Site

Pushkin, 196603, Russia
GSK Investigational Site

Saint Petersburg, 197022, Russia
GSK Investigational Site

Cheongju Chungcheongbuk-do, 28644, South Korea
GSK Investigational Site

Daegu, 42601, South Korea
GSK Investigational Site

Gyeonggi-do, 10408, South Korea
GSK Investigational Site

Pusan, 49241, South Korea
GSK Investigational Site

Seongnam-si Gyeonggi-do, 13620, South Korea
GSK Investigational Site

Seoul, 03722, South Korea
GSK Investigational Site

Seoul, 05505, South Korea
GSK Investigational Site

Seoul, 06351, South Korea
GSK Investigational Site

Seoul, 08308, South Korea
GSK Investigational Site

Suwon Kyunggi-do, 443-721, South Korea
GSK Investigational Site

A Coruña, 15006, Spain
GSK Investigational Site

Badalona, 08916, Spain
GSK Investigational Site

Barcelona, 08035, Spain
GSK Investigational Site

Barcelona, 08036, Spain
GSK Investigational Site

Burgos, 09006, Spain
GSK Investigational Site

Córdoba, 140044, Spain
GSK Investigational Site

Las Palmas de Gran Canar, 35016, Spain
GSK Investigational Site

Madrid, 28007, Spain
GSK Investigational Site

Madrid, 28034, Spain
GSK Investigational Site

Madrid, 28041, Spain
GSK Investigational Site

Madrid, 28046, Spain
GSK Investigational Site

Madrid, 28050, Spain
GSK Investigational Site

Madrid, 28222, Spain
GSK Investigational Site

Málaga, 29010, Spain
GSK Investigational Site

Valencia, 46026, Spain
GSK Investigational Site

Gävle, SE-801 87, Sweden
GSK Investigational Site

Stockholm, 171 64, Sweden
GSK Investigational Site

Uppsala, SE-751 85, Sweden
GSK Investigational Site

Taipei, 11217, Taiwan
GSK Investigational Site

Dusit, 10300, Thailand
GSK Investigational Site

Kho Hong Hat Yai, 90110, Thailand
GSK Investigational Site

Khon Kaen, 40002, Thailand
GSK Investigational Site

Pathum Thani, 12120, Thailand
GSK Investigational Site

Adana, 1120, Turkey (Türkiye)
GSK Investigational Site

Antalya, 07020, Turkey (Türkiye)
GSK Investigational Site

Izmir, 35600, Turkey (Türkiye)
GSK Investigational Site

Cardiff, CF14 2TL, United Kingdom
GSK Investigational Site

Edinburgh, EH4 2XU, United Kingdom
GSK Investigational Site

London, SE1 9RT, United Kingdom
GSK Investigational Site

London, W1G 6AD, United Kingdom
GSK Investigational Site

Manchester, M20 4BX, United Kingdom

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