New shot aims to tame dangerous COPD attacks

NCT ID NCT06040086

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether a new injectable medication called tozorakimab can help people with chronic obstructive pulmonary disease (COPD) who experience frequent symptom flare-ups. The trial will enroll over 1,400 adults who are already on standard inhaled medications but still have breathing attacks. Researchers will compare the injection to a placebo to see if it safely reduces the number and severity of these flare-ups and improves daily breathing and quality of life.

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Locations

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Birmingham, Alabama, 35205, United States
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Decatur, Alabama, 35603, United States
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Sheffield, Alabama, 35660, United States
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Phoenix, Arizona, 85027, United States
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Tucson, Arizona, 85704, United States
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Yuma, Arizona, 85365, United States
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Los Angeles, California, 90027, United States
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Newport Beach, California, 92663, United States
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San Francisco, California, 94109, United States
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Westminster, California, 92683, United States
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Aurora, Colorado, 80014, United States
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Boulder, Colorado, 80301, United States
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Washington D.C., District of Columbia, 20037, United States
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Boynton Beach, Florida, 33435, United States
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Cape Coral, Florida, 33990, United States
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Lakeland, Florida, 33805, United States
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Lakeland, Florida, 33813, United States
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Naples, Florida, 34102, United States
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Ocala, Florida, 34470, United States
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Ormond Beach, Florida, 32174, United States
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Atlanta, Georgia, 30344, United States
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Lithonia, Georgia, 30038, United States
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Champaign, Illinois, 61820, United States
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Chicago, Illinois, 60607, United States
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Chicago, Illinois, 60616, United States
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Andover, Kansas, 67002, United States
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Bowling Green, Kentucky, 42101, United States
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Lexington, Kentucky, 40503, United States
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Towson, Maryland, 21286, United States
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Detroit, Michigan, 48202, United States
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Minneapolis, Minnesota, 55425, United States
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Chesterfield, Missouri, 63005, United States
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Chesterfield, Missouri, 63017, United States
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Hannibal, Missouri, 63401, United States
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Papillion, Nebraska, 68046, United States
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Las Vegas, Nevada, 89102, United States
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Toms River, New Jersey, 08755, United States
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The Bronx, New York, 10451, United States
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Charlotte, North Carolina, 28273, United States
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Greenville, North Carolina, 27834, United States
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Huntersville, North Carolina, 28078, United States
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Winston-Salem, North Carolina, 27103, United States
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Dayton, Ohio, 45439, United States
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Lima, Ohio, 45801, United States
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Grants Pass, Oregon, 97527, United States
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Gaffney, South Carolina, 29340, United States
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Union, South Carolina, 29379, United States
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Chattanooga, Tennessee, 37404, United States
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Elizabethton, Tennessee, 37643, United States
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Jackson, Tennessee, 38305, United States
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Dallas, Texas, 75254, United States
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El Paso, Texas, 79902, United States
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Houston, Texas, 77008, United States
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McKinney, Texas, 75069, United States
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San Antonio, Texas, 78258, United States
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Roy, Utah, 84067, United States
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Kenosha, Wisconsin, 53142, United States
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Buenos Aires, C1121 ABE, Argentina
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CABA, C1025ABI, Argentina
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CABA, C1425BEN, Argentina
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Ciudad de Buenos Aires, C1414AIF, Argentina
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Córdoba, X5003DCE, Argentina
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La Plata, B1904, Argentina
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Mar del Plata, 7600, Argentina
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Mar del Plata, B7600GWV, Argentina
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Mendoza, M5500CCG, Argentina
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Quilmes, B1878FNR, Argentina
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San Fernando, B1646EBJ, Argentina
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San Juan Bautista, 1888, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Brussels, 1070, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Kortrijk, 8500, Belgium
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Leuven, 3000, Belgium
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Mechelen, 2800, Belgium
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Namur, 5101, Belgium
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Roeselare, 8800, Belgium
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Barretos, 14784-400, Brazil
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Belo Horizonte, 30150-221, Brazil
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Blumenau, 89030-101, Brazil
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Campina Grande do Sul, 83.430-000, Brazil
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Campinas, 13060-080, Brazil
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Fortaleza, 60430-270, Brazil
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Porto Alegre, 90035074, Brazil
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Porto Alegre, 90610-000, Brazil
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Porto Alegre, 91010-006, Brazil
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São Bernardo do Campo, 09715090, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 05403-000, Brazil
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Valinhos, 13271-130, Brazil
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Dupnitsa, 2600, Bulgaria
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Haskovo, 6300, Bulgaria
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Panagyurishte, 4500, Bulgaria
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Plovdiv, 4003, Bulgaria
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Sofia, 1756, Bulgaria
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Veliko Tanovo, 5000, Bulgaria
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Yambol, 8600, Bulgaria
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Calgary, Alberta, T3R 1W7, Canada
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Kelowna, British Columbia, V1Y 4N7, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Burlington, Ontario, L7N 3V2, Canada
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Toronto, Ontario, M5T 3A9, Canada
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Winchester, Ontario, K0C 2K0, Canada
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Lévis, Quebec, G6V 0C9, Canada
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Québec, Quebec, G1V 4G5, Canada
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Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
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Chile, 7770484, Chile
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Concepción, 4070094, Chile
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Quillota, 2260000, Chile
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Santiago, 7500010, Chile
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Santiago, 7501126, Chile
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Santiago, 7750495, Chile
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Santiago, 8380453, Chile
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Viña del Mar, 2540488, Chile
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Beijing, 100029, China
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Changchun, 130021, China
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Changsha, 410015, China
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Changsha, 430033, China
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Chengdu, 610014, China
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Chengdu, 610072, China
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Chengdu, 611130, China
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Chongqing, 400037, China
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Chongqing, 400042, China
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Guangzhou, 510145, China
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Guangzhou, 510163, China
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Guangzhou, 510515, China
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Hefei, 230061, China
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Hohhot, 750306, China
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Huizhou, 516002, China
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Jinan, 250001, China
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Lanzhou, 730030, China
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Liaocheng, 252000, China
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Linhai, 317000, China
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Nanchang, 330006, China
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Nanchong, 637000, China
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Nanjing, 210006, China
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Nanjing, 210009, China
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Nanning, 530021, China
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Ningbo, 315010, China
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Pingxiang, 337055, China
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Qingdao, 266000, China
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Shanghai, 200040, China
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Shanghai, 200240, China
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Shanghai, 200433, China
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Shanghai, 201199, China
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Shenyang, 110004, China
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Shenyang, 110016, China
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Shenzhen, 518020, China
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Shijiazhuang, 050051, China
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Shijiazhuang, 50051, China
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Taizhou, 318000, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Xi'an, 710006, China
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Xuzhou, 221000, China
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Xuzhou, 221009, China
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Yinchuan, 750004, China
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Zigong, 643000, China
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Aalborg, 9000, Denmark
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Aarhus, 8200, Denmark
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Hvidovre, 2650, Denmark
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København NV, 2400, Denmark
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Næstved, 4700, Denmark
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Roskilde, 4000, Denmark
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Vejle, 7100, Denmark
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Aix-en-Provence, 13100, France
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Brest, 29609, France
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Colmar, 68024, France
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Epagny Metz-Tessy, 74370, France
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La Tronche, 38700, France
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Lyon, 69317, France
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Marseille, 13015, France
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Montpellier, 34295, France
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Quimper, 29000, France
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Reims, 51092, France
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Villefranche-sur-Saône, 69655, France
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Augsburg, 86150, Germany
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Berlin, 10119, Germany
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Berlin, 10717, Germany
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Berlin, 10787, Germany
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Berlin, 10961, Germany
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Berlin, 12157, Germany
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Berlin, 12159, Germany
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Berlin, 12203, Germany
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Berlin, 13187, Germany
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Cologne, 51069, Germany
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Darmstadt, 64283, Germany
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Essen, 45127, Germany
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Frankfurt, 60596, Germany
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Frankfurt am Main, 60389, Germany
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Großhansdorf, 22927, Germany
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Halle, 06108, Germany
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Halle, 06120, Germany
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Hanover, 30159, Germany
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Leipzig, 04299, Germany
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Marburg, 35037, Germany
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Moers, 47441, Germany
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München, 80335, Germany
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München-Pasing, 81241, Germany
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Nuremberg, 90419, Germany
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Peine, 31224, Germany
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Solingen, 42699, Germany
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Athens, 11521, Greece
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Athens, 17562, Greece
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Heraklion, 71409, Greece
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Thessaloniki, 57010, Greece
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Budapest, 1203, Hungary
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Debrecen, 4032, Hungary
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Edelény, 3780, Hungary
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Encs, 3860, Hungary
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Gödöllő, 2100, Hungary
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Hajdúnánás, 4080, Hungary
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Mosonmagyaróvár, 9200, Hungary
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Pécs, 7635, Hungary
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Százhalombatta, 2440, Hungary
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Szolnok, 5000, Hungary
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Ajmer, 305001, India
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Calicut, 673 008, India
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Dehradun, 248001, India
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Delhi, 110029, India
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Dwārka, 110075, India
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Hyderabad, 500035, India
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Hyderabad, 500038, India
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Jaipur, 302012, India
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Jaipur, 302039, India
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Kolkata, 700053, India
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Nagpur, 440012, India
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Vijayawada, 520 008, India
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Visakhapatnam, 530017, India
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Cork, T12 DV56, Ireland
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Dublin, D24 NR0A, Ireland
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Galway, H91 YR71, Ireland
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Moneymore, A92 VW28, Ireland
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Cona, 44124, Italy
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Foggia, 71100, Italy
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Modena, 41124, Italy
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Naples, 80131, Italy
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Padua, 35128, Italy
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Pavia, 27100, Italy
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Pisa, 56100, Italy
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Roma, 161, Italy
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Aomori, 030-8553, Japan
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Asahikawa-shi, 070-8644, Japan
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Chikushino-shi, 818-8502, Japan
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Chūōku, 104-0031, Japan
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Fujieda-shi, 426-8677, Japan
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Fukuoka, 814-0180, Japan
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Ginowan-shi, 901-2214, Japan
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Habikino-shi, 583-8588, Japan
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Hakodate-shi, 041-8680, Japan
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Hamamatsu, 430-8525, Japan
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Itabashi-ku, 173-8610, Japan
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Izumi-shi, 594-0073, Japan
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Kagoshima, 892-0847, Japan
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Kobe, 650-0047, Japan
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Kusatsu-shi, 525-8585, Japan
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Kyoto, 612-8555, Japan
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Matsusaka-shi, 515-8544, Japan
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Minoh, 562-0003, Japan
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Minokamo Shi, 505-8510, Japan
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Mizunami-shi, 509-6134, Japan
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Morioka, 020-0066, Japan
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Nagoya, 457-8511, Japan
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Nankoku-shi, 783-8505, Japan
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Nankoku-shi, 783-8509, Japan
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Omuta-shi, 837-0911, Japan
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Sagamihara-shi, 252-0143, Japan
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Sagamihara-shi, 252-0315, Japan
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Sakaide-shi, 762-8550, Japan
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Sapporo, 006-8555, Japan
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Sapporo, 064-0804, Japan
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Shizuoka, 420-8630, Japan
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Tachikawa-shi, 190-8531, Japan
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Toon-shi, 791-0281, Japan
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Toshima-ku, 171-0014, Japan
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Toyonaka-shi, 560-8552, Japan
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Ube, 755-8505, Japan
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Yanagawa-shi, 832-0059, Japan
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Yokohama, 221-0855, Japan
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Yokohama, 232-0024, Japan
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Yokohama, 232-0066, Japan
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Yokohama, 236-0037, Japan
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Alor Star, 5460, Malaysia
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Kajang, 43000, Malaysia
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Kota Bharu, 15586, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuantan, 25100, Malaysia
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Seremban, 70300, Malaysia
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Mexico City, 03310, Mexico
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's-Hertogenbosch, 5223 GZ, Netherlands
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Arnhem, 6815 AD, Netherlands
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Breda, 4818 CK, Netherlands
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Heerlen, 6419 PC, Netherlands
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Roermond, 6043 CV, Netherlands
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Rotterdam, 3045 PM, Netherlands
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Rotterdam, 3083 AN, Netherlands
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Zutphen, 7207 AE, Netherlands
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Lima, 15046, Peru
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Lima, 15102, Peru
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Lima, LIMA 21, Peru
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Piura, 20001, Peru
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Santa Beatriz, LIMA 14, Peru
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Bialystok, 15-044, Poland
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Bydgoszcz, 85-796, Poland
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Chrzanów, 32-500, Poland
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Kielce, 25-426, Poland
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Krakow, 30-033, Poland
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Krakow, 31-513, Poland
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Pruszków, 05-800, Poland
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Płock, 09-407, Poland
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Rzeszów, 35-205, Poland
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Anyang-si, 14068, South Korea
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Daegu, 42415, South Korea
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Incheon, 21565, South Korea
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Jeonju, 54907, South Korea
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Seoul, 04763, South Korea
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Seoul, 05030, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 06973, South Korea
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Wŏnju, 26426, South Korea
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Badalona(Barcelona), 08916, Spain
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Barcelona, 08035, Spain
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Cáceres, 10003, Spain
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Madrid, 28850, Spain
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Málaga, 29010, Spain
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Mérida, 06800, Spain
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Santander, 39008, Spain
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Zaragoza, 50009, Spain
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Hat Yai, 90110, Thailand
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Khlong Luang, 12120, Thailand
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Muang, 22000, Thailand
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Muang, 40002, Thailand
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Mueang, 20000, Thailand
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Nakhon Ratchasima, 30000, Thailand
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Adana, 1330, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Mersin, 33343, Turkey (Türkiye)
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Chernivtsi, 58022, Ukraine
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Ivano-Frankivsk, 76019, Ukraine
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Kyiv, 02002, Ukraine
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Kyiv, 02081, Ukraine
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Kyiv, 03037, Ukraine
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Kyiv, 03680, Ukraine
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Tarasove Village, 45634, Ukraine
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Ternopil, 46001, Ukraine
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Uzhhorod, 88018, Ukraine
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Vinnytsia, 21001, Ukraine
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Vinnytsia, 21029, Ukraine
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Zhytomyr, 100002, Ukraine
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Bradford, BD9 6RJ, United Kingdom
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Cottingham, HU16 5JQ, United Kingdom
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Glasgow, G4 0SF, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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Liverpool, L7 8XP, United Kingdom
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London, EC1M 6BQ, United Kingdom
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London, NW3 2QG, United Kingdom
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Macclesfield, SK10 3BL, United Kingdom
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Newcastle upon Tyne, NE7 7AF, United Kingdom
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Portsmouth, PO6 3LY, United Kingdom
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Wakefield, WF1 4DG, United Kingdom
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Hanoi, 100000, Vietnam
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Hanoi, 10000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam
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Hochiminh, 70000, Vietnam

Conditions

Explore the condition pages connected to this study.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)