New shot aims to tame dangerous COPD attacks

NCT ID NCT05166889

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing whether two different doses of an injectable medication called tozorakimab can help people with COPD who frequently experience symptom flare-ups (exacerbations). Over 1,100 adults with moderate-to-severe COPD who are already on standard inhaler therapy will receive either the new drug or a placebo injection to see if it safely reduces the number of flare-ups and improves breathing and quality of life over one year.

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Contacts and locations

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Locations

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Huntsville, Alabama, 35801, United States
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Mobile, Alabama, 36608, United States
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Montgomery, Alabama, 36106, United States
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Tempe, Arizona, 85283, United States
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Bakersfield, California, 93301, United States
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Sacramento, California, 95821, United States
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Boynton Beach, Florida, 33435, United States
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Ormond Beach, Florida, 32174, United States
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Plantation, Florida, 33324, United States
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Meridian, Idaho, 83642, United States
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Evergreen Park, Illinois, 60805, United States
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Normal, Illinois, 61761, United States
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Iowa City, Iowa, 52242, United States
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Kansas City, Kansas, 66104, United States
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Baton Rouge, Louisiana, 70816, United States
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Zachary, Louisiana, 70791, United States
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Baltimore, Maryland, 21224, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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Missoula, Montana, 59808, United States
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Brick, New Jersey, 08724, United States
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New York, New York, 10037, United States
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The Bronx, New York, 10455, United States
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Charlotte, North Carolina, 28277, United States
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Durham, North Carolina, 27710, United States
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Gastonia, North Carolina, 28054, United States
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Fargo, North Dakota, 58104, United States
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DuBois, Pennsylvania, 15801, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Sayre, Pennsylvania, 18840, United States
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Rapid City, South Dakota, 57702, United States
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Franklin, Tennessee, 37067, United States
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Houston, Texas, 77022, United States
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Kingwood, Texas, 77339, United States
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Salt Lake City, Utah, 84108, United States
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Burlington, Vermont, 05401, United States
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Buenos Aires, C1121 ABE, Argentina
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CABA, C1425BEN, Argentina
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Ciudad de Buenos Aires, C1414AIF, Argentina
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Córdoba, X5003DCE, Argentina
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Mar del Plata, 7600, Argentina
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Mar del Plata, B7600GWV, Argentina
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Mendoza, M5500CCG, Argentina
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Quilmes, B1878FNR, Argentina
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San Fernando, B1646EBJ, Argentina
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San Juan Bautista, 1888, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Brussels, 1000, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Namur, 5101, Belgium
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Dupnitsa, 2600, Bulgaria
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Haskovo, 6305, Bulgaria
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Kozloduy, 3320, Bulgaria
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Lovech, 5500, Bulgaria
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Petrich, 2850, Bulgaria
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Pleven, 5800, Bulgaria
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Rousse, 7002, Bulgaria
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Sliven, 8800, Bulgaria
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Sofia, 1000, Bulgaria
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Sofia, 1606, Bulgaria
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Troyan Municipality, 5600, Bulgaria
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Vratsa, 3000, Bulgaria
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Calgary, Alberta, T3E 7M8, Canada
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Edmonton, Alberta, T5A 4L8, Canada
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Sherwood Park, Alberta, T8L 0N2, Canada
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Kamloops, British Columbia, V2C 5T1, Canada
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Kelowna, British Columbia, V1Y 4N7, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Guelph, Ontario, N1H 6J2, Canada
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Markham, Ontario, L3T 0C8, Canada
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Stouffville, Ontario, L4A 1H2, Canada
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Winchester, Ontario, K0C 2K0, Canada
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Montreal, PQ, H3T 1E2, Canada
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Québec, Quebec, G1G 5X1, Canada
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Québec, Quebec, G1V 4G5, Canada
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Terrebonne, Quebec, J6V 2H2, Canada
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Brno, 625 00, Czechia
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Broumov, 55001, Czechia
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Jindřichův Hradec, 377 01, Czechia
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Liberec, 460 63, Czechia
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Olomouc, 779 00, Czechia
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Rokycany, 337 22, Czechia
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Aalborg, 9000, Denmark
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Hvidovre, 2650, Denmark
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København NV, 2400, Denmark
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Næstved, 4700, Denmark
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Roskilde, 4000, Denmark
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Vejle, 7100, Denmark
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Hämeenlinna, 13530, Finland
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Helsinki, 00290, Finland
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Kuopio, 70210, Finland
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Tampere, 33520, Finland
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Turku, 20100, Finland
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Turku, 20520, Finland
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Budapest, 1036, Hungary
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Debrecen, 4032, Hungary
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Edelény, 3780, Hungary
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Encs, 3860, Hungary
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Mosonmagyaróvár, 9200, Hungary
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Nyíregyháza-Sóstóhegy, 4481, Hungary
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Százhalombatta, 2440, Hungary
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Ahmedabad, 382415, India
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Belagavi, 590010, India
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Coimbatore, 641028, India
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Dehradun, 248001, India
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Hyderabad, 500038, India
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Jaipur, 302039, India
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Mohali, 160062, India
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Nagpur, 440012, India
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Nashik, 422007, India
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New Delhi, 110029, India
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Surat, 395009, India
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Thane, 401107, India
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Asahikawa-shi, 078-8510, Japan
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Chikushino-shi, 818-8502, Japan
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Chūōku, 103-0022, Japan
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Fujieda-shi, 426-8677, Japan
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Fukuoka, 819-8555, Japan
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Hamamatsu, 430-8525, Japan
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Hamamatsu, 431-3192, Japan
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Hiroshima, 734-8530, Japan
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Iizuka-shi, 820-8505, Japan
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Itabashi-ku, 173-8610, Japan
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Iwata-shi, 438-8550, Japan
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Joyo-shi, 610-0113, Japan
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Kagoshima, 890-8520, Japan
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Kanazawa, 920-8650, Japan
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Kawachinagano-shi, 586-8521, Japan
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Kitakyusyu-shi, 806-8501, Japan
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Kobe, 651-0072, Japan
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Koga-shi, 811-3195, Japan
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Kokubunji-shi, 185-0014, Japan
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Matsusaka-shi, 515-8544, Japan
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Mizunami-shi, 509-6134, Japan
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Nagaoka-shi, 940-8621, Japan
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Nagoya, 460-0001, Japan
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Obihiro, 080-0017, Japan
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Okayama, 700-8558, Japan
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Osaka, 531-0073, Japan
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Osaka, 543-8555, Japan
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Osaka, 545-8586, Japan
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Sakaishi, 590-0064, Japan
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Shinjuku-ku, 162-8655, Japan
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Shizuoka, 420-8630, Japan
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Toshima-ku, 170-0003, Japan
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Toyonaka-shi, 560-8552, Japan
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Yanagawa-shi, 832-0059, Japan
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Yokohama, 221-0855, Japan
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Yokohama, 223-0059, Japan
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Yokohama, 232-0024, Japan
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Benito Juárez, 03650, Mexico
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Chihuahua City, 31000, Mexico
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Guadalajara, 44100, Mexico
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Guadalajara, 44200, Mexico
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Mexico City, 0 3100, Mexico
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Mérida, 97070, Mexico
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Monterrey, 64460, Mexico
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Morelia, 58000, Mexico
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Oaxaca City, 68020, Mexico
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Veracruz, 91910, Mexico
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Alkmaar, 1815 JD, Netherlands
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Eindhoven, 5623EJ, Netherlands
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Groningen, 9713 GZ, Netherlands
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Harderwijk, 3844 DG, Netherlands
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Heerlen, 6419 PC, Netherlands
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Zutphen, 7207 AE, Netherlands
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Zwolle, 8025 AB, Netherlands
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Ålesund, 6017, Norway
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Bergen, 5021, Norway
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Bodø, 8092, Norway
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Levanger, 7600, Norway
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Lørenskog, 1478, Norway
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Oslo, 0450, Norway
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Tønsberg, 3103, Norway
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Guimarães, 4835-235, Portugal
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Lisbon, 1769-001, Portugal
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Lisbon, 1998-018, Portugal
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Matosinhos Municipality, 4454-509, Portugal
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Vila Franca de Xira, 2600-009, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Guaynabo, 00968, Puerto Rico
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Daegu, 42415, South Korea
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Incheon, 21431, South Korea
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Jeonju, 54907, South Korea
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Seoul, 03722, South Korea
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Seoul, 05030, South Korea
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Seoul, 05505, South Korea
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Seoul, 06591, South Korea
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Seoul, 07061, South Korea
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Galdakao, 48960, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Mérida, 06800, Spain
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Pozuelo de Alarcón, 28223, Spain
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Santander, 39008, Spain
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Valencia, 46010, Spain
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Zaragoza, 50009, Spain
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Gothenburg, 413 45, Sweden
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Gothenburg, 413 46, Sweden
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Lund, 222 22, Sweden
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Malmo, 205 02, Sweden
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Stockholm, 11239, Sweden
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Ankara, 06620, Turkey (Türkiye)
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Aydin, 09100, Turkey (Türkiye)
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Istanbul, 34069, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)
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Izmir, 35965, Turkey (Türkiye)
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Mersin, 33343, Turkey (Türkiye)
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam

Conditions

Explore the condition pages connected to this study.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)