New drug combo aims to overcome resistance in hard-to-treat lung cancer

NCT ID NCT04895579

First seen Nov 18, 2025 · Last updated Apr 28, 2026 · Updated 22 times

Summary

This early-phase study tested whether adding the drug copanlisib to the standard immunotherapy durvalumab could help patients with stage III non-small cell lung cancer that cannot be removed by surgery. The study included 11 people who had already received chemotherapy and radiation. The main goal was to see if the combination was safe and tolerable, and to check if it could improve the immune system's ability to fight the cancer.

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Contacts and locations

Locations

  • Markey Cancer Center

    Lexington, Kentucky, 40536, United States

Conditions

Explore the condition pages connected to this study.