New vaginal ring aims to give women more birth control choices

NCT ID NCT03432416

Completed Disease control Sponsor: Premier Research Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 2 trial tested a vaginal ring that releases two hormones (Nestorone and estradiol) to prevent pregnancy. 385 healthy women aged 18-35 took part. The study compared two different ways of using the ring (continuous vs. cyclic) to see how well it works and how it affects bleeding patterns.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nestorone and estradiol vaginal ring
What this could lead to: If successful, this could provide a new, effective birth control option that women can use themselves.
What could go wrong: This is a Phase 2 trial, so it's still early. The ring may not prevent pregnancy as well as expected, or side effects could limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FEMALE CONTRACEPTION HEALTHY WOMEN

Contacts and locations

Locations

Bellevue Hospital Center

New York, New York, 10016, United States
Columbia University

New York, New York, 10032, United States
Eastern Virginia Medical School

Norfolk, Virginia, 23507, United States
Essential Access Health

Los Angeles, California, 30010, United States
Johns Hopkins Bayview Medical Center

Baltimore, Maryland, 21224, United States
Oregon Health Science University

Portland, Oregon, 97239, United States
University of California, Davis

Sacramento, California, 95817, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Colorado Denver

Aurora, Colorado, 80045, United States
University of Pennsylvania School of Medicine

Philadelphia, Pennsylvania, 19104, United States
University of Utah

Salt Lake City, Utah, 84132, United States

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