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New hope for lung cancer: Drug-Radiation combo trial opens

NCT ID NCT04550104

Recruiting now Disease control Sponsor: University of Leeds Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for people with a type of advanced lung cancer (non-small cell) that cannot be treated with surgery or standard chemo-radiation. It tests adding experimental drugs that block DNA repair to standard radiation therapy, followed by a year of immunotherapy (durvalumab). The main goal is to find the safest dose of these drug combinations and check for side effects over about 13 months. Around 200 participants will take part across multiple centers.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • Addenbrooke's Hospital

    RECRUITING

    Cambridge, United Kingdom

  • Belfast City Hospital

    RECRUITING

    Belfast, United Kingdom

  • Birmingham Heartlands Hospital

    RECRUITING

    Birmingham, United Kingdom

  • Freeman Hospital, Newcastle upon Tyne Hospitals NHS Trust

    RECRUITING

    Newcastle upon Tyne, United Kingdom

  • St Bartholomew's Hospitals

    RECRUITING

    London, United Kingdom

  • St James's University Hospital

    RECRUITING

    Leeds, United Kingdom

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, United Kingdom

  • The Clatterbridge Cancer Centre

    RECRUITING

    Liverpool, United Kingdom

  • The Royal Marsden Hospital Chelsea

    RECRUITING

    Chelsea, United Kingdom

  • The Royal Marsden Sutton

    RECRUITING

    Sutton, United Kingdom

  • University College Hospital London

    RECRUITING

    London, United Kingdom

  • Velindre Cancer Centre

    RECRUITING

    Cardiff, United Kingdom

  • Western General Hospital

    RECRUITING

    Edinburgh, United Kingdom

  • Weston Park Hospital

    RECRUITING

    Sheffield, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.