Cure My Disease

Don't miss your cure!

 Log in / Sign up

Scientists seek standard dose swap for septic shock drugs

NCT ID NCT06499467

Knowledge-focused Sponsor: Sanjay Gandhi Postgraduate Institute of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 16, 2026 · Last updated Oct 16, 2026

Summary

Septic shock is a life-threatening condition where blood pressure drops dangerously low. Doctors often use norepinephrine as the first-choice drug to raise blood pressure, but they may add other drugs like vasopressin, phenylephrine, or epinephrine. This study aims to find out what dose of these other drugs equals a standard dose of norepinephrine. Researchers will carefully switch drugs in 120 adult patients on breathing machines and measure how much of the new drug is needed to keep blood pressure steady.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vasopressin, phenylephrine, and epinephrine compared with norepinephrine
What this could lead to
If it works, this could give doctors a standard way to compare different blood pressure drugs, which may help them choose the right one for each patient.
What could go wrong
The study is small and only looks at one moment in treatment, so the results may not apply to all patients or all situations. Changing vasopressors can cause blood pressure to swing, which carries risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

120 people

The number who actually took part.

Started

Jul 2024

Finished

Jan 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All adult patients on mechanical ventilation who are in septic shock condition receiving norepinephrine as vasopressor

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All adult patients on mechanical ventilation in septic shock receiving norepinephrine in whom the treating clinical team plan to add another vasopressor, will be considered for inclusion if they meet these two condition (1) Patient is on Norepinephrine infusion at least 0.1 mcg/kg/min for the last 6 hours; and (2) There has been no dose alteration in the infusion of norepinephrine for the last 2 hours Exclusion Criteria: * There are concurrently other forms of shock like cardiogenic, obstructive, anaphylactic or hypovolemic. * The patient has arrhythmias during the current course of illness. * The patient has asynchrony on mechanical ventilator despite airway clearance with suctioning and adequate sedation at the time of study measurement. * The patient is hypovolemic with ongoing fluid resuscitation in the form of fluid boluses, blood or blood product transfusions at the time of study measurement. * The patient receives diuretic boluses or undergoes hemodialysis sessions at the time of study measurement. * Pregnancy * Patient who didn't consent for study or withdrew the consent at any point of the study.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Septic shock are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Septic shock

Contacts and locations

Locations

  • Sanjay Gandhi Postgraduate Institute of Medical Sciences

    Lucknow, Uttar Pradesh, 226014, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.