New balloon and laser combo may save legs and money

NCT ID NCT02599389

Completed Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested three ways to treat leg arteries that have reblocked after stent placement: standard balloon angioplasty, a drug-coated balloon, and a laser plus drug-coated balloon. The goal was to see which approach is most cost-effective over 18 months. The trial involved 222 adults with symptoms like leg pain or poor circulation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: drug-coated balloon (paclitaxel) and excimer laser
What this could lead to: If successful, this could identify a more cost-effective way to treat reblocked stents in leg arteries, potentially improving blood flow and reducing the need for repeat procedures.
What could go wrong: This is a completed phase 3 trial, but the results may not apply to all patients. The treatments carry risks like vessel damage or recurrence of blockage, and the cost benefits may vary.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANGIOPLASTY, BALLOON

Contacts and locations

Locations

Centre Hospitalier Universitaire de Besançon

Besançon, 25030, France
Centre Hospitalier Universitaire de Clermont-Ferrand

Clermont-Ferrand, 63000, France
Centre Hospitalier Universitaire de Dijon

Dijon, 21079, France
Centre Hospitalier Universitaire de Nantes

Nantes, 44093, France
Centre Hospitalier Universitaire de St Etienne

Saint-Etienne, 42055, France
Centre Hospitalier Universitaire de Strasbourg

Strasbourg, 67091, France
Clinique Pasteur

Toulouse, 31076, France
Clinique Rhône Durance

Avignon, 84000, France
Clinique de L'Europe

Rouen, 76100, France
Hospices Civils de Lyon

Lyon, 69000, France
Hôpital Européen Georges Pompidou - AP-HP de Paris

Paris, 75015, France
Polyclinique Les Fleurs

Ollioules, 83190, France
University Hospital of Bordeaux - Hospital Pellegrin

Bordeaux, 33000, France

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