Lung cancer showdown: which drug combo works best?
NCT ID NCT07394062
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study follows 400 people with advanced non-small cell lung cancer whose tumors have low PD-L1 levels (below 50%). Researchers will compare two standard treatment combos: chemotherapy plus pembrolizumab versus nivolumab plus ipilimumab with chemotherapy. The goal is to see which approach leads to longer survival and better quality of life in everyday medical practice.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pembrolizumab, nivolumab, ipilimumab, and platinum-based chemotherapy
What this could lead to
If successful, this study could help doctors choose the best treatment for advanced lung cancer patients with low PD-L1 levels, improving survival and quality of life.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by patient differences. It won't prove one treatment is better, only provide real-world insights.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Ankara Etlik City Hospital
RECRUITINGAnkara, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gazi University Faculty of Medicine, Department of Medical Oncology
RECRUITINGAnkara, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••