New dye test could replace risky X-Rays for frostbite diagnosis
NCT ID NCT05777590
First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 4 times
Summary
This pilot study compares two imaging methods—ICG microangiography and conventional angiography—in 8 adults with severe frostbite. The goal is to see if the safer ICG dye test can accurately show damaged tissue, potentially replacing the standard angiogram that uses contrast dye with kidney risks. If they match, doctors may have a simpler, safer way to assess frostbite severity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Indocyanine Green (ICG) dye
- What this could lead to
- If successful, this could show that ICG microangiography is a reliable alternative to conventional angiography for diagnosing severe frostbite, potentially simplifying diagnosis and reducing risks from contrast dye.
- What could go wrong
- This is a very small pilot study with only 8 participants, so results may not apply broadly. The study is not testing a treatment, only comparing imaging methods, so it won't directly improve frostbite outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Regions Hospital
Saint Paul, Minnesota, 55101, United States
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