New hope for Tough-to-Treat colon cancer: major trial tests promising combo

NCT ID NCT05425940

Ongoing Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new two-drug combination (XL092 + atezolizumab) works better than the current standard drug (regorafenib) for people with advanced colorectal cancer that has spread and stopped responding to other treatments. It involves about 900 participants whose cancer has a specific genetic profile (MSS/MSI-low). The main goal is to see if the new combination helps people live longer compared to the standard option.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Exelixis Clinical Site #1

Omaha, Nebraska, 68130, United States
Exelixis Clinical Site #10

Westwood, Kansas, 66205, United States
Exelixis Clinical Site #100

Singapore, 168583, Singapore
Exelixis Clinical Site #101

Tainan, 704, Taiwan
Exelixis Clinical Site #102

Indianapolis, Indiana, 46250, United States
Exelixis Clinical Site #103

Pittsburgh, Pennsylvania, 15232, United States
Exelixis Clinical Site #104

Wellington, 6021, New Zealand
Exelixis Clinical Site #105

Orange, California, 92868, United States
Exelixis Clinical Site #106

Philadelphia, Pennsylvania, 19107, United States
Exelixis Clinical Site #107

Kaohsiung City, 833, Taiwan
Exelixis Clinical Site #108

Almada, 2805-267, Portugal
Exelixis Clinical Site #109

Dresden, 01307, Germany
Exelixis Clinical Site #11

New York, New York, 10016, United States
Exelixis Clinical Site #110

Birmingham, B95SS, United Kingdom
Exelixis Clinical Site #111

Edinburgh, EH42XU, United Kingdom
Exelixis Clinical Site #112

Barcelona, 08908, Spain
Exelixis Clinical Site #113

Frankfurt am Main, 60488, Germany
Exelixis Clinical Site #114

London, W1G 6AD, United Kingdom
Exelixis Clinical Site #115

Romford, RM70AG, United Kingdom
Exelixis Clinical Site #116

Madrid, 28007, Spain
Exelixis Clinical Site #117

Bedford Park, 5042, Australia
Exelixis Clinical Site #118

Liuying, 73657, Taiwan
Exelixis Clinical Site #119

Guishan, 333, Taiwan
Exelixis Clinical Site #12

Oklahoma City, Oklahoma, 73142, United States
Exelixis Clinical Site #120

Coimbra, 3000-075, Portugal
Exelixis Clinical Site #121

Zaragoza, 50009, Spain
Exelixis Clinical Site #122

Győr, 9024, Hungary
Exelixis Clinical Site #123

London, EC1A 7BE, United Kingdom
Exelixis Clinical Site #124

Lisbon, 1649-035, Portugal
Exelixis Clinical Site #125

New Haven, Connecticut, 06510, United States
Exelixis Clinical Site #126

Sutton, SM2 5PT, United Kingdom
Exelixis Clinical Site #127

Hanover, Niedersach, 30625, Germany
Exelixis Clinical Site #128

Nyíregyháza, Szabolcs-Szatmar-Bereg County, 4400, Hungary
Exelixis Clinical Site #129

Budapest, 1122, Hungary
Exelixis Clinical Site #13

Seattle, Washington, 98101, United States
Exelixis Clinical Site #130

Bristol, England, BS2 8ED, United Kingdom
Exelixis Clinical Site #131

Lisbon, 1500-650, Portugal
Exelixis Clinical Site #132

Singapore, 119228, Singapore
Exelixis Clinical Site #133

Nashville, Tennessee, 37232, United States
Exelixis Clinical Site #14

Roanoke, Virginia, 24014, United States
Exelixis Clinical Site #15

Albuquerque, New Mexico, 87131, United States
Exelixis Clinical Site #16

Miami Beach, Florida, 33140, United States
Exelixis Clinical Site #17

The Bronx, New York, 10461, United States
Exelixis Clinical Site #18

Pittsburgh, Pennsylvania, 15212, United States
Exelixis Clinical Site #19

Melbourne, 3002, Australia
Exelixis Clinical Site #2

Spokane, Washington, 99208, United States
Exelixis Clinical Site #20

Bydgoszcz, 85-796, Poland
Exelixis Clinical Site #21

Barcelona, 08025, Spain
Exelixis Clinical Site #22

St Louis, Missouri, 63141, United States
Exelixis Clinical Site #23

Melbourne, 3021, Australia
Exelixis Clinical Site #24

Greenville, South Carolina, 29607, United States
Exelixis Clinical Site #25

Hong Kong, Hong Kong
Exelixis Clinical Site #26

Siedlce, 08-110, Poland
Exelixis Clinical Site #27

Port Macquarie, 2444, Australia
Exelixis Clinical Site #28

Hwasun, 58128, South Korea
Exelixis Clinical Site #29

Gyeonggi-do, 14068, South Korea
Exelixis Clinical Site #3

Joliet, Illinois, 60435, United States
Exelixis Clinical Site #30

Phoenix, Arizona, 85004, United States
Exelixis Clinical Site #31

Warsaw, 02-507, Poland
Exelixis Clinical Site #32

Seattle, Washington, 98104, United States
Exelixis Clinical Site #33

Hong Kong, Hong Kong
Exelixis Clinical Site #34

Seoul, 03080, South Korea
Exelixis Clinical Site #35

Namur, 5000, Belgium
Exelixis Clinical Site #36

Goyang-si, 10408, South Korea
Exelixis Clinical Site #37

Seongnam-si, 13620, South Korea
Exelixis Clinical Site #38

Paris, 75020, France
Exelixis Clinical Site #39

Singapore, 217562, Singapore
Exelixis Clinical Site #4

Marietta, Georgia, 30060, United States
Exelixis Clinical Site #40

Seoul, South Korea
Exelixis Clinical Site #41

Budapest, 1097, Hungary
Exelixis Clinical Site #42

Tomaszów Mazowiecki, 97-200, Poland
Exelixis Clinical Site #43

Antwerp, 2300, Belgium
Exelixis Clinical Site #44

Seoul, 08308, South Korea
Exelixis Clinical Site #45

Seoul, 03722, South Korea
Exelixis Clinical Site #450

Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #46

Seoul, 06351, South Korea
Exelixis Clinical Site #47

Lexington, Kentucky, 40536, United States
Exelixis Clinical Site #48

Debrecen, 4302, Hungary
Exelixis Clinical Site #49

Dunedin, 9016, New Zealand
Exelixis Clinical Site #5

Santa Rosa, California, 95403, United States
Exelixis Clinical Site #51

Brussels, 1200, Belgium
Exelixis Clinical Site #52

Besançon, 25030, France
Exelixis Clinical Site #53

Bankstown, 2200, Australia
Exelixis Clinical Site #54

Seoul, 06591, South Korea
Exelixis Clinical Site #55

La Jolla, California, 92037, United States
Exelixis Clinical Site #56

Chattanooga, Tennessee, 37404, United States
Exelixis Clinical Site #57

Auckland, 1023, New Zealand
Exelixis Clinical Site #58

Torrance, California, 90505, United States
Exelixis Clinical Site #59

New York, New York, 10029, United States
Exelixis Clinical Site #6

Cincinnati, Ohio, 45219, United States
Exelixis Clinical Site #60

Orlando, Florida, 32804, United States
Exelixis Clinical Site #61

Hamburg, 20249, Germany
Exelixis Clinical Site #62

Chiang Mai, 50200, Thailand
Exelixis Clinical Site #63

Hamburg, 22763, Germany
Exelixis Clinical Site #64

Woodville South, 5011, Australia
Exelixis Clinical Site #65

Jonesboro, Alabama, 72401, United States
Exelixis Clinical Site #66

Seoul, 05505, South Korea
Exelixis Clinical Site #67

Madrid, 28041, Spain
Exelixis Clinical Site #68

Opole, 45-061, Poland
Exelixis Clinical Site #69

Hamilton, 3204, New Zealand
Exelixis Clinical Site #7

New Orleans, Louisiana, 70112, United States
Exelixis Clinical Site #70

Tucson, Arizona, 85719, United States
Exelixis Clinical Site #71

Lyon, 69008, France
Exelixis Clinical Site #72

Madrid, 28034, Spain
Exelixis Clinical Site #73

Taichung, 40447, Taiwan
Exelixis Clinical Site #74

Charlotte, North Carolina, 28204, United States
Exelixis Clinical Site #75

Portland, Oregon, 97210, United States
Exelixis Clinical Site #76

Nashville, Tennessee, 37203, United States
Exelixis Clinical Site #77

Los Angeles, California, 90095, United States
Exelixis Clinical Site #78

Barcelona, 08023, Spain
Exelixis Clinical Site #79

Madrid, 28050, Spain
Exelixis Clinical Site #8

Billings, Montana, 59102, United States
Exelixis Clinical Site #80

Santa Monica, California, 90404, United States
Exelixis Clinical Site #81

Whittier, California, 90602, United States
Exelixis Clinical Site #82

Sylmar, California, 91342, United States
Exelixis Clinical Site #83

Albury, 2640, Australia
Exelixis Clinical Site #84

Dijon, 21079, France
Exelixis Clinical Site #85

Kaohsiung City, 807, Taiwan
Exelixis Clinical Site #86

Barcelona, 08035, Spain
Exelixis Clinical Site #87

Marseille, 13385, France
Exelixis Clinical Site #88

Herbault, 34298, France
Exelixis Clinical Site #89

Seattle, Washington, 98109, United States
Exelixis Clinical Site #9

Duarte, California, 91010, United States
Exelixis Clinical Site #90

Valencia, 46014, Spain
Exelixis Clinical Site #91

München, 81737, Germany
Exelixis Clinical Site #92

Hat Yai, 90110, Thailand
Exelixis Clinical Site #93

Suresnes, 92150, France
Exelixis Clinical Site #94

Singapore, 329563, Singapore
Exelixis Clinical Site #95

Lleida, 25198, Spain
Exelixis Clinical Site #96

Lisbon, 400-038, Portugal
Exelixis Clinical Site #97

Heidelberg, 3084, Australia
Exelixis Clinical Site #98

Singapore, 258499, Singapore
Exelixis Clinical Site #99

Guimarães, 4835-044, Portugal

Conditions

Explore the condition pages connected to this study.

COLORECTAL CANCER