New hope for Tough-to-Treat colon cancer: targeted combo enters final testing

NCT ID NCT05198934

Ongoing Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

Summary

This study is for people with advanced colorectal cancer that has a specific genetic change called KRAS G12C and has worsened after at least one prior treatment. It aims to see if a new combination of two targeted drugs (sotorasib and panitumumab) works better and is safer than the current standard treatment options. About 160 participants will be randomly assigned to receive either the new drug combination or one of the standard treatments.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Agios Loukas Clinic

Thessaloniki, 55236, Greece
Aichi Medical University Hospital

Nagakute-shi, Aichi-ken, 480-1195, Japan
Asan Medical Center

Seoul, 05505, South Korea
Azienda Ospedaliera Cardinale Giovanni Panico

Tricase, 73039, Italy
Azienda Ospedaliera Rilievo Nazionale e Alta Specializzazione Garibaldi Nesima

Catania, 95122, Italy
Azienda Ospedaliera San Carlo

Potenza, 85100, Italy
Azienda Ospedaliera San Giovanni Addolorata

Roma, 00184, Italy
Azienda Ospedaliera Santa Croce e Carle

Confreria (CN), 12100, Italy
Azienda Ospedaliera Universitaria Careggi

Florence, 50134, Italy
Azienda Ospedaliera Universitaria Pisana Ospedale Santa Chiara

Pisa, 56126, Italy
Azienda Ospedaliero Universitaria Luigi Vanvitelli

Naples, 80131, Italy
Azienda Ospedaliero Universitaria Maggiore della Carita

Novara, 28100, Italy
Azienda Ospedaliero Universitaria di Cagliari Policlinico Duilio Casula

Monserrato CA, 09042, Italy
Azienda Sanitaria Locale 5 Spezzino Ospedale S Andrea

La Spezia, 19100, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
Azienda Unita Locale Socio Sanitaria Berica 8

Vicenza, 36100, Italy
Azienda Unita Sanitaria Locale LE Presidio Ospedaliero Vito Fazzi Polo Oncologico Giovanni Paolo II

Lecce, 73100, Italy
Azienda Unita Sanitaria Locale di Reggio Emilia Arcispedale Santa Maria Nuova

Reggio Emilia, 42100, Italy
Beatson West of Scotland Cancer Centre

Glasgow, G12 0YN, United Kingdom
Best Cancer Care & Hematology

Houston, Texas, 77089, United States
Cancer Specialists of North Florida

Jacksonville, Florida, 32256, United States
Central Alabama Research

Birmingham, Alabama, 35209, United States
Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot

Lyon Cédex 3, 69437, France
Charite Universitaetsmedizin Berlin, Charité Campus Virchow-Klinikum

Berlin, 13353, Germany
Chiba Cancer Center

Chiba, Chiba, 260-8717, Japan
Chris OBrien Lifehouse

Camperdown, New South Wales, 2050, Australia
City of Hope National Medical Center

Duarte, California, 91010, United States
Complexo Hospitalario Universitario de Ourense

Ourense, Galicia, 32005, Spain
Evgenidio Hospital I Agia Trias

Athens, 11528, Greece
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy
Fondazione Policlinico Tor Vergata

Roma (RM), 00133, Italy
General Hospital of Athens Laiko

Athens, 11527, Greece
GenesisCare -North Shore (Oncology)

St Leonards, New South Wales, 2065, Australia
Health Pharma Professional Research SA de CV

Mexico City, Mexico City, 03100, Mexico
Hokkaido University Hospital

Sapporo, Hokkaido, 060-8648, Japan
Hospital General Universitario de Elche

Elche, Valencia, 03203, Spain
Hospital General Universitario de Valencia

Valencia, Valencia, 46014, Spain
Hospital Universitari Vall d Hebron

Barcelona, Catalonia, 08035, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008, Spain
Hospital Universitario Reina Sofia

Córdoba, Andalusia, 14004, Spain
Hospital Universitario Virgen de las Nieves

Granada, Andalusia, 18014, Spain
Hospital Universitario de Navarra

Pamplona, Navarre, 31008, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Catalonia, 08041, Spain
Hygeia Hospital

Athens, 15123, Greece
Hyogo Cancer Center

Akashi-shi, Hyōgo, 673-8558, Japan
Hôpital Européen Georges Pompidou

Paris, 75015, France
Hôpital Haut -lévêque

Pessac, 33604, France
Institut regional du Cancer Montpellier

Montpellier, 34298, France
Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale

Naples, 80131, Italy
Istituto Oncologico Veneto IRCCS

Padua, 35128, Italy
Istituto Ospedaliero Fondazione Poliambulanza

Brescia, 25124, Italy
Johns Hopkins University School of Medicine

Washington D.C., District of Columbia, 20016, United States
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center

Yokohama, Kanagawa, 241-8515, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 80756, Taiwan
Kelsey Research Foundation

Houston, Texas, 77025, United States
Klinikum der Universitaet Muenchen Campus Grosshadern

München, 81377, Germany
Lakes Research LLC

Miami Lakes, Florida, 33014, United States
Lancaster General Hospital Ann B Barshinger Cancer Institute

Lancaster, Pennsylvania, 17601, United States
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

Taoyuan District, 33305, Taiwan
Lumi Research

Kingwood, Texas, 77339, United States
Maidstone Hospital

Maidstone, ME16 9QQ, United Kingdom
Moses H Cone Memorial Hospital

Greensboro, North Carolina, 27403, United States
Mount Vernon Cancer Centre

Northwood, HA6 2RN, United Kingdom
National Cancer Center Hospital

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa-shi, Chiba, 277-8577, Japan
National Cheng Kung University Hospital

Tainan, 70403, Taiwan
National Hospital Organization Kyushu Cancer Center

Fukuoka, Fukuoka, 811-1395, Japan
National Hospital Organization Osaka National Hospital

Osaka, Osaka, 540-0006, Japan
National Hospital Organization Shikoku Cancer Center

Matsuyama, Ehime, 791-0280, Japan
National Taiwan University Hospital

Taipei, 10002, Taiwan
Northwest Georgia Oncology Centers PC

Marietta, Georgia, 30060, United States
Osaka University Hospital

Suita-shi, Osaka, 565-0871, Japan
Ospedale Policlinico San Martino IRCCS

Genova, 16132, Italy
Policlinico Universitario Agostino Gemelli

Roma, 00168, Italy
Revive Research Institute

Farmington Hills, Michigan, 48334, United States
Revive Research Institute

Sterling Heights, Michigan, 48314, United States
Royal Free Hospital

London, NW3 2QG, United Kingdom
Royal Marsden Hospital

London, SW3 6JJ, United Kingdom
Royal Marsden Hospital

Sutton, SM2 5PT, United Kingdom
Saitama Cancer Center

Kitaadachi-gun, Saitama, 362-0806, Japan
Samsung Medical Center

Seoul, 06351, South Korea
Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Shizuoka Cancer Center

Sunto-gun, Shizuoka, 411-8777, Japan
Sparrow Clinical Research Institute

Lansing, Michigan, 48912, United States
St Marianna University Hospital

Kawasaki-shi, Kanagawa, 216-8511, Japan
Superare Centro de Infusion SA de CV

Mexico City, Mexico City, 06760, Mexico
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research

Koto-ku, Tokyo, 135-8550, Japan
The Mark H Zangmeister Center

Columbus, Ohio, 43210, United States
The Queen Elizabeth Hospital

Woodville South, South Australia, 5011, Australia
Theagenion Anticancer Hospital

Thessaloniki, 54007, Greece
Trials In Medicine SC

Mexico City, 06700, Mexico
Universitaetsklinikum Carl Gustav Carus an der Technischen Universitaet Dresden

Dresden, 01307, Germany
Universitaetsklinikum der Eberhard Karls Universitaet Tuebingen

Tübingen, 72076, Germany
Universitaetsmedizin Goettingen - Georg-August-Universitaet

Göttingen, 37075, Germany
University Hospital of Heraklion

Heraklion - Crete, 71500, Greece
University Hospital of Patras

Pátrai, 26504, Greece
University of California Irvine

Orange, California, 92868, United States
University of Michigan

Ann Arbor, Michigan, 48106-0995, United States
Upstate University Hospital

Syracuse, New York, 13210, United States
Westmead Hospital

Westmead, New South Wales, 2145, Australia
White Plains Hospital Center for Cancer Care

White Plains, New York, 10601, United States

Conditions

Explore the condition pages connected to this study.

COLORECTAL CANCER (CRC)