New drug combo tested for Tough-to-Treat colon cancer

NCT ID NCT03377361

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This study tested whether combining the immunotherapy drug nivolumab with the targeted therapy trametinib, with or without another immunotherapy called ipilimumab, could help control advanced colorectal cancer that had spread and stopped responding to prior treatments. It involved 325 people whose cancer had progressed despite previous therapies. The main goals were to find safe doses and see if the combinations could shrink tumors or slow their growth.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Local Institution

Woluwe-Saint-Lambert, 1200, Belgium
Local Institution - 0001

San Francisco, California, 94158, United States
Local Institution - 0002

Madison, Wisconsin, 53792-0001, United States
Local Institution - 0003

Philadelphia, Pennsylvania, 19104, United States
Local Institution - 0004

Hanover, 30625, Germany
Local Institution - 0022

Birmingham, Alabama, 35249, United States
Local Institution - 0027

Los Angeles, California, 90033, United States
Local Institution - 0028

Baltimore, Maryland, 21287, United States
Local Institution - 0029

Charlotte, North Carolina, 28204, United States
Local Institution - 0043

Southport, Queensland, 4215, Australia
Local Institution - 0044

Blacktown, New South Wales, 2148, Australia
Local Institution - 0051

Madrid, 28041, Spain
Local Institution - 0052

Barcelona, 08035, Spain
Local Institution - 0055

Clayton, Victoria, 0, Australia
Local Institution - 0067

Los Angeles, California, 90089, United States
Local Institution - 0068

Elizabeth Vale, South Australia, 05112, Australia
Local Institution - 0069

Heidelberg, Victoria, 3084, Australia
Local Institution - 0070

Toronto, Ontario, M5G 2M9, Canada
Local Institution - 0071

Brno, 65653, Czechia
Local Institution - 0072

Olomouc, Olomoucký kraj, 779 00, Czechia
Local Institution - 0073

Hradec Králové, 500 05, Czechia
Local Institution - 0076

Ottawa, K1H 8L6, Canada
Local Institution - 0077

Montreal, Quebec, H2X 0A9, Canada
Local Institution - 0079

Badalona, Barcelona [Barcelona], 08916, Spain
Local Institution - 0080

Pamplona, Navarre, 31009, Spain
Local Institution - 0092

Padua, 35128, Italy
Local Institution - 0093

Milan, 20133, Italy
Local Institution - 0094

Rozzano, 20089, Italy
Local Institution - 0095

Catania, 95124, Italy
Local Institution - 0096

Seville, 41013, Spain
Local Institution - 0100

Lancaster, Pennsylvania, 17604, United States
Local Institution - 0101

Temple, Texas, 76508, United States
Local Institution - 0103

St Louis, Missouri, 63110, United States
Local Institution - 0104

New York, New York, 10016, United States
Local Institution - 0107

Gainesville, Florida, 32610, United States
Local Institution - 0111

Miami, Florida, 33136, United States
Local Institution - 0113

Edmonton, Alberta, T6G 1Z2, Canada
Local Institution - 0114

Madrid, 28007, Spain
Local Institution - 0115

Madrid, 28050, Spain
Local Institution - 0116

Hattiesburg, Mississippi, 39401-7233, United States
Local Institution - 0117

Santiago, Santiago Metropolitan, 000000, Chile
Local Institution - 0118

Santiago, Santiago Metropolitan, 8420383, Chile
Local Institution - 0119

Buenos Aires, 1431, Argentina
Local Institution - 0120

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina
Local Institution - 0122

Buenos Aires, Distrito Federal, C1096AAS, Argentina
Local Institution - 0123

Buenos Aires, Distrito Federal, 1181, Argentina
Thomas Jefferson University - Clinical Research Institute

Philadelphia, Pennsylvania, 19107, United States

Conditions

Explore the condition pages connected to this study.

COLORECTAL CANCER COLORECTAL CARCINOMA COLORECTAL NEOPLASM COLORECTAL TUMORS