New scale aims to better track nerve disease in kids

NCT ID NCT01203085

Completed Knowledge-focused Sponsor: University of Iowa Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study created and tested a new scale called the CMT Pediatric Scale to measure symptoms and physical function in children with Charcot-Marie-Tooth disease. Researchers enrolled 500 children under 21 with CMT types 1, 2, or 4 at multiple centers. The scale assesses foot and hand symptoms, strength, sensation, balance, and motor skills to improve monitoring of the disease over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this scale could become a standard tool for tracking CMT in children, helping doctors and researchers better understand the disease and evaluate future treatments.
What could go wrong: This is an observational study to develop a measurement tool, not a treatment trial. The scale may not capture all important aspects of the disease or may need further refinement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Charcot-Marie-Tooth disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHARCOT-MARIE-TOOTH DISEASE

Contacts and locations

Locations

C. Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, Italy
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Westmead

Sydney, New South Wales, 2145, Australia
Dubowitz Neuromuscular Centre

London, UK, United Kingdom
National Hospital of Neurology and Neurosurgery

London, England, WC1N 3BG, United Kingdom
Nemours Children's Clinic

Orlando, Florida, 32827, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Stanford University

Palo Alto, California, 94305, United States
The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
University of Connecticut/Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of North Carolina

Chapel Hill, North Carolina, 27514, United States
University of Rochester

Rochester, New York, 14642, United States

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