Blood thinner helps dialysis fistulas stay open, but doesn't guarantee usability

NCT ID NCT03289520

First seen Oct 31, 2025 · Last updated May 16, 2026 · Updated 29 times

Summary

This study tested whether the blood thinner clopidogrel can prevent early failure of arteriovenous fistulas (connections between an artery and vein) in people with kidney failure who need hemodialysis. 877 adults were enrolled. The drug reduced the risk of fistula blockage but did not increase the chance that the fistula could be used successfully for dialysis. This means clopidogrel helps keep the access open but does not solve all problems needed for effective dialysis.

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Contacts and locations

Locations

  • Boston University Medical Center

    Boston, Massachusetts, 02118, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Maine Medical Center

    Portland, Maine, 04102, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Texas Southwestern

    Dallas, Texas, 75390, United States

  • Vanderbilt University

    Nashville, Tennessee, 37232, United States

  • Wake Forest University

    Winston-Salem, North Carolina, 27157, United States

  • Washington University

    St Louis, Missouri, 63110, United States

Conditions

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