New drug targets rare lung cancer mutation

NCT ID NCT04036682

Ongoing Disease control Sponsor: Cullinan Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called CLN-081 in people with advanced non-small cell lung cancer that has a specific genetic change (EGFR exon 20 insertion). Participants must have already received chemotherapy. The goal is to see if the drug is safe and can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

CLN-081 (zipalertinib)

What this could lead to

If successful, this could provide a new targeted treatment option for people with a hard-to-treat form of lung cancer.

What could go wrong

This is an early-phase trial, so the drug may not work as hoped or could cause significant side effects. Results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EGFR EXON 20 MUTATION NON-SMALL-CELL LUNG CANCER

Contacts and locations

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Locations

AdventHealth

Orlando, Florida, 32804, United States
Ajou University Hospital

Suwon, South Korea
Asan Medical Center (AMC)

Soeul, South Korea
Azienda Ospedaliero Universitaria Careggi

Careggi, Italy
Azienda Ospedaliero Universitaria Modena

Modena, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I

Marche, Italy
Chang Gung Medical Foundation Chiayi Chang Gung Memorial Hospital

Chiayi City, Taiwan
Chung Shan Medical University Hospital

Taichung, Taiwan
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
City of Hope at Irvine Lennar

Irvine, California, 92618, United States
Clinica Universidad de Navarra

Pamplona, Spain
Columbia University Irving Medical Center

New York, New York, 10032, United States
Complejo Hospitalario Universitario Insular Materno Infantil

Las Palmas, Spain
Gabrail Cancer Center Research

Canton, Ohio, 44701, United States
Gachon University Gil Medical Center

Incheon, South Korea
Hong Kong University - Queen Mary Hospital

Hong Kong, Hong Kong
Hospital Clinic i Provincial de Barcelona

Barcelona, Spain
Hospital General Universitario Gregorio Maranon (HGUGM)

Madrid, Spain
Hospital Parc Tauli

Barcelona, Spain
Hospital Regional Universitario de Malaga

Málaga, Spain
Hospital Universitario Puerta de Hierro de Majadahonda

Madrid, Spain
Hospital Universitario Vall d'Hebron

Barcelona, Spain
IRCCS-Istituto Europeo di Oncologia

Milan, Italy
Inha University Hospital

Incheon, South Korea
Institut Catala d'Oncologia l'Hospitalet

Barcelona, Spain
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS

Meldola, Italy
Korea University Guro Hospital

Soeul, South Korea
Leiden University Medical Center

Leiden, 2333 ZA, Netherlands
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
National Cancer Center

Goyang-si, South Korea
National Cancer Center Hospital

Tokyo, Japan
National Cancer Center Hospital East

Chiba, Japan
National Cancer Centre Singapore

Singapore, 169610, Singapore
National Taiwan University Hospital

Taipei, 10002, Taiwan
New York University Langone Health

New York, New York, 10016, United States
Niigata Cancer Center

Niigata, Japan
Osaka City General Hospital

Osaka, Japan
Osaka International Cancer Institute

Osaka, Japan
Ospedale Santa Maria delle Croci

Ravenna, Italy
Pacific Cancer Medical Center, Inc

Anaheim, California, 92801, United States
Pacific Shores Medical Group

Long Beach, California, 90813, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States
Providence Cancer Center

Portland, Oregon, 97213, United States
Providence Oncology & Hematology Care Clinic-Westside

Portland, Oregon, 97225, United States
START Barcelona

Barcelona, Spain
Samsung Medical Center

Seoul, South Korea
San Gerardo Hospital

Monza, Italy
Seoul National University Bundang Hospital (SNUBH)

Gyeonggi-do, South Korea
Shizuoka Cancer Center

Shizuoka, Japan
Singapore Clinical Research Institute

Singapore, 138669, Singapore
Summit Medical Group PA

Florham Park, New Jersey, 07932, United States
Taichung Veterans General Hospital

Taichung, Taiwan
Taipei Medical University Hospital

Taipei, Taiwan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research

Tokyo, Japan
The Catholic University Of Korea St. Vincent's Hospital

Suwon, South Korea
The Netherlands Cancer Institute (NKI)

Amsterdam, 1066 CX, Netherlands
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur)

Valencia, Spain
University Hospital A Coruna

A Coruña, Spain
University Hospital Quironsalud Madrid

Madrid, Spain
University of Michigan Health System - University Hospital

Ann Arbor, Michigan, 48109, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States