Major study weighs bladder removal against drug therapy for cancer patients

NCT ID NCT03933826

Ongoing Knowledge-focused Sponsor: University of Washington Source: ClinicalTrials.gov ↗

First seen Nov 05, 2025 · Last updated Apr 28, 2026 · Updated 24 times

Summary

This study compares two treatments for people with a type of bladder cancer that keeps coming back: medication placed directly into the bladder or surgery to remove the bladder. Researchers want to see which option gives patients a better quality of life. About 570 adults with high-risk, non-muscle-invasive bladder cancer are taking part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Albert Einstein College of Medicine

The Bronx, New York, 10461, United States
Asante Rogue Regional Medical Center

Medford, Oregon, 97504, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Carolina Urologic Research Center, LLC

Myrtle Beach, South Carolina, 29572, United States
Chesapeake Urology Research Associates

Hanover, Maryland, 21076, United States
Comprehensive Urology -- A Division of Michigan Healthcare Professionals

Royal Oak, Michigan, 48073, United States
Emory University

Atlanta, Georgia, 30322, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
H. Lee Moffitt Cancer Center & Research Institute

Tampa, Florida, 33612, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Johns Hopkins University, School of Medicine

Baltimore, Maryland, 21231, United States
LSU Healthcare Network - Multi Specialty Clinic

Metairie, Louisiana, 70006, United States
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Mayo Clinic Cancer Center

Phoenix, Arizona, 85054, United States
Michigan Medicine Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
Perelman Center for Advanced Medicine

Philadelphia, Pennsylvania, 19122, United States
Spectrum Health

Grand Rapids, Michigan, 49503, United States
Stephenson Cancer Center

Oklahoma City, Oklahoma, 73114, United States
The Ohio State University

Columbus, Ohio, 43210, United States
The University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
UCLA

Los Angeles, California, 90095, United States
USC/Norris Comprehensive CA Center

Los Angeles, California, 90033, United States
UT Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Miami

Miami, Florida, 33136, United States
University of North Carolina

Chapel Hill, North Carolina, 27599, United States
University of Utah

Salt Lake City, Utah, 84132, United States
University of Washington

Seattle, Washington, 98195, United States
Urology Associates, P.C.

Nashville, Tennessee, 37209, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.

BLADDER CANCER CANCER OF THE BLADDER, RECURRENT NON-MUSCLE-INVASIVE BLADDER CANCER