Could a simple cervical swab replace biopsy for endometrial cancer detection?

This study aims to see if a new DNA test (CISENDO) on cells from a routine cervical smear can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. About 3,500 participants will provide a cervical sample and undergo standard hysteroscopy for comparison. Some will be followed for up to a year to monitor changes. If successful, this test could offer a less invasive way to screen for and track endometrial lesions.