Could a cholera vaccine stop Kids' diarrhea?
NCT ID NCT07300462
First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 2 times
Summary
This large study tests whether an oral cholera vaccine can also protect children aged 2 to 14 from infectious diarrhea caused by other germs. 6,000 healthy kids will get either the vaccine or a placebo. The goal is to see if the vaccine lowers the number of diarrhea cases, building on earlier hints of broader protection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- oral recombinant subunit B/bacterial cholera vaccine (enteric-coated capsules)
- What this could lead to
- If successful, this vaccine could help prevent common infectious diarrhea in children, reducing illness and antibiotic use.
- What could go wrong
- This is a large phase 4 trial, but the vaccine is being tested for a new use (non-cholera diarrhea). It may not work as well in real-world conditions, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anhui Provincial Center for Disease Control and Prevention
Hefei, Anhui, China
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Hubei Provincial Center for Disease Control and Prevention
Wuhan, Hubei, China
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Jiangsu Provincial Center for Disease Control and Prevention
Nanjing, Jiangsu, China
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National Institute for Communicable Disease Control and Prevention, China
Beijing, Beijing Municipality, China
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Shandong Provincial Center for Disease Control and Prevention
Jinan, Shandong, China
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