Could neck adjustments relieve Cancer-Related fatigue?
NCT ID NCT06235671
First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This trial tests whether six weeks of upper cervical chiropractic care can help adults who have finished cancer treatment but still struggle with chronic fatigue. The study focuses on whether such a trial is practical, looking at recruitment, adherence, and acceptability. Participants are cancer survivors aged 18 to 65 with no active disease. The results will guide a future, larger study on chiropractic care for cancer-related fatigue.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Upper cervical chiropractic care, a procedure involving 6 weeks of chiropractic sessions
- What this could lead to
- If this trial succeeds, it could point toward a non-drug way to ease chronic fatigue in cancer survivors, and support a larger study to confirm the benefit.
- What could go wrong
- This is a small feasibility trial, not a proof of effectiveness. It may not show clear benefits, and chiropractic care carries rare risks like injury from neck manipulation.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Expected to start
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Oct 2024
An estimate. Start dates often move.
- Expected to finish
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May 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Able to understand and provide written informed consent in English * 18-65 years of age * Informed by primary health care provider that there is no evidence of active disease (this is sometimes referred to as "complete remission" or "cured") * Minimum of 3 months since completion of primary curative-intent cancer therapies including surgery, chemotherapy, radiotherapy, and/or immunotherapy (long-term hormonal therapy permitted) * Onset of fatigue occurred at some point during illness and/or treatment * FACIT-Fatigue scale score in the moderate-to-severe range (i.e., at or above the 60th percentile) * If on any prescription medication (including hormonal therapy), on a stable dose for a minimum of 12 weeks with no plans to change medications or doses during the study Exclusion Criteria: * Taking any short-acting benzodiazepine including midazolam \& triazolam * Known disorder resulting in syncope/fainting during postural changes (e.g., postural orthostatic tachycardia syndrome, orthostatic hypotension) * Pacemaker or known heart condition that influences the electrical or mechanical function of the heart (e.g., severe heart valve disease) * Diagnosed with an externalizing (e.g., substance use, antisocial disorder) or thought (e.g., schizophrenia, paranoid personality, bipolar) disorder that is uncontrolled or untreated * Diagnosed with rheumatoid arthritis, osteoporosis, or cervical spine instability * Currently pregnant * Current litigation related to a physical, health-related injury * Chronic pain rated at least 3/10 on a visual analog scale (VAS)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dr. Sid E. Williams Center for Chiropractic Research
Atlanta, Georgia, 30308, United States
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