Texts and calls put to the test to keep heart failure patients on their meds
NCT ID NCT07831538
First seen Sep 21, 2026 · Last updated Sep 21, 2026
Summary
Kaiser Permanente researchers are testing whether digital outreach helps adults with heart failure refill medications they have let lapse. Participants are assigned to receive either interactive text messages or automated phone calls encouraging refills, or usual care with no extra outreach. The study tracks refill records, hospitalizations, and deaths over 12 months to see whether the reminders make a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- digital outreach through interactive text messages or automated telephone calls
- What this could lead to
- If it works, health systems could use their existing text and phone channels to help people with heart failure keep up with life-saving medications, reducing hospital stays.
- What could go wrong
- A reminder alone may not overcome cost, side effects, or forgetfulness, and any benefit seen in one large health system may not carry over to others. The trial measures refills and hospital records, not whether people feel better.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 13,714 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥18 years 2. Active KPNC membership 3. Heart failure diagnosis documented at least 6 months before the index date, with a documented EF 4. Prescribed at least one eligible GDMT medication and maintained on a stable dose for ≥6 months: 1. HFpEF (EF≥50%): ARNI (sacubitril/valsartan); MRA; SGLT2i 2. HFrEF or HFmrEF (EF \<50%): ARNI (sacubitril/valsartan), ACEi, or ARB; Beta-blocker (bisoprolol, carvedilol, or sustained-release metoprolol succinate); MRA; SGLT2i 5. At least one unfilled refill for an eligible GDMT medication that is 7-13 days overdue at index Exclusion Criteria: 1. Documented allergy or intolerance to all eligible GDMT medications for which the patient is overdue 2. Receiving hospice or comfort-focused care 3. Skilled nursing facility stay within prior 12 months 4. No valid telephone number on file through which the patient could be reached by text message or automated telephone call 5. Opted out of receiving pharmacy medication adherence outreach from Kaiser Permanente 6. Other conditions that prevent outreach
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Kaiser Permanente Division of Research
Pleasanton, California, 94588, United States
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