New pill shows promise for Tough-to-Treat blood cancers

NCT ID NCT04756726

Ongoing Disease control Sponsor: C4 Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new oral drug called cemsidomide (CFT7455) in about 224 adults with non-Hodgkin's lymphoma or multiple myeloma that has returned or not responded to prior therapies. The study aims to find safe doses and check for side effects, both when the drug is used alone and, for myeloma patients, in combination with dexamethasone. It is not yet known if the drug will shrink tumors or improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cemsidomide (also called CFT7455), taken as a pill, sometimes with dexamethasone
What this could lead to: If it works, this could offer a new treatment option for people with blood cancers that have stopped responding to other therapies.
What could go wrong: This is a very early (Phase 1/2) trial, so the drug may not work or may have serious side effects. It is only for people who have already tried other treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma plasma cell myeloma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA, NON-HODGKIN'S MULTIPLE MYELOMA

Contacts and locations

Locations

Colorado Blood Cancer Institute (Sarah Cannon Research Institute)

Denver, Colorado, 80218, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Phoenix, Arizona, 85054, United States
Mayo Clinic

Jacksonville, Florida, 32224, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Mt Sinai Medical Center

New York, New York, 10029, United States
Tennessee Oncology (Sarah Cannon Research Institute)

Nashville, Tennessee, 37203, United States
University of California-San Francisco

San Francisco, California, 94143, United States
Washington University School of St. Louis

St Louis, Missouri, 63110, United States

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