Could a single CF gene copy change your infection risk?

NCT ID NCT05474430

Recruiting now Knowledge-focused Sponsor: Philip Polgreen Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is recruiting 160 people — half who carry one copy of the cystic fibrosis (CF) gene and half who do not — to see if carriers have different risks for respiratory infections. Researchers will collect nasal cells and blood samples to measure how well the cells move chloride and bicarbonate, how acidic the airway surface is, and how thick mucus is. The goal is to understand whether carrying one CF gene affects the body's ability to fight off respiratory infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If this study finds differences, it could help explain why some people get more severe respiratory infections and point toward new ways to prevent or treat them.
What could go wrong: This is an observational study, not a treatment trial. It is small and early, so any findings will need much more research before they could lead to practical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

respiratory tract infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARRIER STATE RESPIRATORY INFECTIONS

Contacts and locations

Locations

University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States

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