Immunotherapy combo shows promise for advanced cervical cancer
NCT ID NCT03894215
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested two immunotherapy drugs, AGEN2034 and AGEN1884, in 211 women with recurrent cervical cancer that had progressed after chemotherapy. One group received AGEN2034 alone, the other received both drugs. The goal was to see if the tumors shrank. The study was terminated early, so results are limited, but it may help guide future research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AGEN2034 (an immunotherapy drug that helps the immune system attack cancer) and AGEN1884 (another immunotherapy drug that boosts immune response)
What this could lead to
If successful, this could point toward a new treatment option for women with recurrent cervical cancer that has not responded to chemotherapy.
What could go wrong
The trial was terminated early, so results are limited. Immunotherapy can cause immune-related side effects, and not all patients respond. The study was small and not designed to compare the two treatments directly.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Albert Einstein College of Medicine
The Bronx, New York, 10461, United States
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Arizona Oncology - Biltmore Cancer Center
Phoenix, Arizona, 85016, United States
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Arizona Oncology - Tucson - Wilmot Road Location
Tucson, Arizona, 85711, United States
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Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207, United States
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CECOR - Centro Oncológico de Roraima
Boa Vista, Roraima, 69304-015, Brazil
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COI Centro Oncológico Internacional S.A.P.I. de C.V.
Mexico City, Mexico City, 04700, Mexico
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CRIO - Centro Regional Integrado de Oncologia
Fortaleza, Ceará, 60336-045, Brazil
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California Pacific Medical Center
San Francisco, California, 94115-1821, United States
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Cancerologia De Queretaro
Querétaro, 76090, Mexico
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Christus Muguerza Hospital Vidriera
Monterrey, Nuevo León, 64570, Mexico
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Clinica MonteSur, Centro de Investigación Clínica Montesur RCI -259
Lima Lima, 15023, Peru
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Columbus NCORP
Columbus, Ohio, 43215, United States
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Community Health Network - North Cancer Center
Indianapolis, Indiana, 46250, United States
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FirstHealth Outpatient Cancer Center
Pinehurst, North Carolina, 28374, United States
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Fundação Antonio Prudente/AC Camargo Cancer Center
São Paulo, 9015-010, Brazil
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Gangnam Severence Hospital
Seoul, 06273, South Korea
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Gynecologic Oncology Associates
Newport, California, 92663, United States
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Hospital Amaral Carvalho
São Paulo, 17210-120, Brazil
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Hospital Mãe de Deus
Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
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Hospital Santa Rita
Vitória, Espírito Santo, 29043-260, Brazil
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Hospital de Câncer de Barretos
Barretos, São Paulo, 14784-400, Brazil
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IMIP - Instituto de Medicina Integral Prof. Fernando Figueira
Recife, Pernambuco, 50070-902, Brazil
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INCA - Instituto Nacional de Câncer
Rio de Janeiro, 20231-050, Brazil
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Instituto do Câncer do Estado de São Paulo
São Paulo, 01246-000, Brazil
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King Chulalongkorn Memorial Hospital, Chulalongkorn University
Bangkok, 10330, Thailand
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Koo Foundation Sun Yat-Sen Cancer Center
Taipei, 11259, Taiwan
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016, United States
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Levine Cancer Institute
Charlotte, North Carolina, 28204, United States
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MD Anderson Cancer Center at Cooper
Camden, New Jersey, 08103, United States
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Mackay Memorial Hospital Taipei Branch
Taipei, 10449, Taiwan
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MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Northside Hospital
Atlanta, Georgia, 30342, United States
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Northwell Health Monter Cancer Center
Lake Success, New York, 11042, United States
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Northwest Cancer Specialists, P.C.
Portland, Oregon, 97227, United States
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ONCOSITE/Hospital de Caridade de Ijuí
Ijuí, Rio Grande do Sul, 98700-000, Brazil
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Oaxaca Site Management Organization (OSMO)
Oaxaca City, 68000, Mexico
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Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
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Oklahoma Cancer Specialists and Research Institute, LLC
Tulsa, Oklahoma, 74146, United States
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Penn Medicine - Jordan Center for Gynecologic Cancer
Philadelphia, Pennsylvania, 19104-5127, United States
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Perola Centro de Pesquisa em Oncologia
São Paulo, 01317-001, Brazil
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Ramathibodi Hospital, Mahidol University
Bangkok, 10400, Thailand
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SUNY Upstate Medical University
Syracuse, New York, 13210, United States
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Samsung Medical Center
Seoul, South Korea
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Seoul National University
Seoul, 03080, South Korea
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St Joseph's Hospital
Savannah, Georgia, 31405-6015, United States
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Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104-5418, United States
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Taichung Veterans General Hospital
Taichung, 40705, Taiwan
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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Texas Oncology
Tyler, Texas, 75702, United States
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Texas Oncology - Bedford
Bedford, Texas, 76022, United States
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Texas Oncology - Dallas - Presbyterian Cancer Center
Dallas, Texas, 75231, United States
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Texas Oncology - Fort Worth Cancer Center
Fort Worth, Texas, 76104, United States
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Texas Oncology - San Antonio Medical Center
San Antonio, Texas, 78240, United States
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Texas Oncology - The Woodlands
The Woodlands, Texas, 77380, United States
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Texas Oncology Surgical Specialists - Austin Central
Austin, Texas, 78745, United States
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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The University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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UCLA- Women's Health Clinical Research Unit (WHCRU)
Los Angeles, California, 90095, United States
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University of Alabama at Birmingham School of Medicine
Birmingham, Alabama, 35233-1802, United States
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University of California, San Diego (UCSD) - Moores Cancer Center
La Jolla, California, 92093, United States
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University of California, San Francisco Medical Center
San Francisco, California, 94158, United States
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University of Kentucky Albert B. Chandler Hospital
Lexington, Kentucky, 40536, United States
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University of New Mexico Cancer Center
Albuquerque, New Mexico, 87102, United States
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University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, 36604, United States
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WellSpan Gynecologic Oncology
York, Pennsylvania, 17403, United States
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Willamette Valley Cancer Institute
Eugene, Oregon, 97401, United States
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Women & Infants Hospital of Rhode Island
Providence, Rhode Island, 02905, United States