Can antibiotic paste heal bone infections without IV drips?
NCT ID NCT06628115
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This study looks at whether placing an antibiotic paste directly into the infected bone during surgery can cure foot bone infections. Adults with foot osteomyelitis will receive the paste instead of six weeks of intravenous antibiotics, followed by a short course of oral antibiotics. Researchers will track healing through clinic visits, x-rays, and questionnaires over a year to see if the infection clears.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cerament V or G, an antibiotic paste implanted into the bone during surgery
- What this could lead to
- If successful, this approach could offer a less burdensome treatment for foot bone infections, potentially reducing the need for prolonged intravenous antibiotics and lowering amputation risk.
- What could go wrong
- This is a small, post-market study, so results may not be definitive. The infection could persist or recur, and there are risks of allergic reactions to the antibiotics or surgical complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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25 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18 years + * Informed consent * Operated on for foot sepsis with limb salvage intent. * Positive bone biopsy from forefoot or midfoot or positive pus culture from exposed bone * Adequate vascularity (1+ palpable pedal pulse, biphasic or triphasic ankle waveforms, or successful revascularisation procedure same admission) * Compliant with offloading footwear and diabetic medication Exclusion Criteria: * Allergy or contraindication to gentamicin/vancomycin * Life expectancy \&amp \<1 year * Unable to make follow up appointments at study centre. * Patients with necrotizing infections * Gentamicin or vancomycin resistant organism * Untreated peripheral arterial disease in angiosome of wound. * Buerger's disease * Vasculitides * Systemic immunosuppressive therapy * Pregnancy * Breastfeeding * Untreated thyrotoxicosis * Mysathenia gravis * Calcium metabolism disorder * Patients taking metformin with estimated glomerular filtration rate (eGFR) \&gt; 30ml/min/1.72m2
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mid and South Essex NHS Foundation Trust
Basildon, Essex, SS16 5NL, United Kingdom
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