Can common penicillins beat stronger antibiotics for bone infections?
NCT ID NCT07266753
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether two different classes of oral antibiotics—beta-lactams (like penicillins) and non-beta-lactams (like fluoroquinolones)—work equally well for treating bone infections in the leg or foot. About 1,400 adults with lower extremity osteomyelitis will be randomly assigned to one of the two antibiotic groups. The goal is to see if the simpler, often cheaper beta-lactam antibiotics are just as effective at curing the infection without needing surgery or switching drugs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Oral antibiotics (beta-lactam and non-beta-lactam classes)
- What this could lead to
- If successful, this trial could show that oral beta-lactam antibiotics are as effective as non-beta-lactams for treating bone infections, offering more treatment options.
- What could go wrong
- This is a feasibility study first, so it may not provide a definitive answer. The results may not apply to all patients or infection types.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Michael Garron Hospital
RECRUITINGToronto, Ontario, M4C 3E7, Canada
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Ottawa Hospital
NOT_YET_RECRUITINGOttawa, Ontario, K1Y 4E9, Canada
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University Health Network
NOT_YET_RECRUITINGToronto, Ontario, M5G 2C4, Canada
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