Can common penicillins beat stronger antibiotics for bone infections?
NCT ID NCT07266753
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether two different classes of oral antibiotics—beta-lactams (like penicillins) and non-beta-lactams (like fluoroquinolones)—work equally well for treating bone infections in the leg or foot. About 1,400 adults with lower extremity osteomyelitis will be randomly assigned to one of the two antibiotic groups. The goal is to see if the simpler, often cheaper beta-lactam antibiotics are just as effective at curing the infection without needing surgery or switching drugs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Oral antibiotics (beta-lactam and non-beta-lactam classes)
What this could lead to
If successful, this trial could show that oral beta-lactam antibiotics are as effective as non-beta-lactams for treating bone infections, offering more treatment options.
What could go wrong
This is a feasibility study first, so it may not provide a definitive answer. The results may not apply to all patients or infection types.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OSTEOMYELITIS OF LOWER EXTREMITIES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Michael Garron Hospital
RECRUITINGToronto, Ontario, M4C 3E7, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Ottawa Hospital
NOT_YET_RECRUITINGOttawa, Ontario, K1Y 4E9, Canada
Contact Email: •••••@•••••
-
University Health Network
NOT_YET_RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact Email: •••••@•••••