Brain scan clue could stop 1 in 5 MS misdiagnoses

NCT ID NCT04495556

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 29 times

Summary

This study looks at whether a specific brain scan feature, called the central vein sign, can help doctors diagnose multiple sclerosis (MS) more accurately. About 420 adults with suspected MS will get MRI scans at the start and after two years. The goal is to see if this sign can reduce the number of people who are wrongly told they have MS and avoid unnecessary treatments.

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Contacts and locations

Locations

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21218, United States

  • St. Michael's Hospital of Unity Health Toronto

    Toronto, Ontario, M5B1W8, Canada

  • The University of Texas at Austin

    Austin, Texas, 78759, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Southern California

    Los Angeles, California, 90089, United States

  • University of Vermont

    Burlington, Vermont, 05405, United States

  • Washington University in St. Louis

    St Louis, Missouri, 63130, United States

  • Yale University

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.