New combo therapy aims to shrink tough rectal tumors before surgery

NCT ID NCT07580339

First seen May 13, 2026 · Last updated May 20, 2026 · Updated 2 times

Summary

This study tests whether adding an experimental drug (DCSZ11) to standard radiation and chemotherapy can improve outcomes for people with a high-risk type of rectal cancer. About 30 adults with mismatch repair proficient (pMMR) locally advanced rectal cancer will receive the combination before surgery. The main goal is to see if the cancer disappears or shrinks significantly, and to check for side effects.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Johns Hopkins SKCCC

    Baltimore, Maryland, 21231, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.