Could a tiny daily pill curb cocaine cravings in opioid patients?
NCT ID NCT05063201
First seen Jan 24, 2026 · Last updated Apr 28, 2026 · Updated 14 times
Summary
This study tested whether a low dose of cariprazine (1.5 mg daily) can help people who are already stable on buprenorphine-naloxone for opioid use disorder also reduce or stop cocaine use. About 26 adults with both opioid and cocaine use disorders took either cariprazine or a placebo for 8 weeks, while providing urine samples twice a week. The goal was to see if cariprazine lowers the number of cocaine-positive urine tests compared to placebo.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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