Engineered immune cells take on lupus in first human trial
NCT ID NCT06333483
First seen Jan 08, 2026 · Last updated May 15, 2026 · Updated 18 times
Summary
This early-stage study tests a new treatment called obecabtagene autoleucel (obe-cel) for people with severe lupus that hasn't responded to other therapies. Obe-cel uses a patient's own immune cells, modified to target and attack faulty B cells driving the disease. The trial aims to check safety and see if it can bring lupus into remission, though ongoing management may still be needed.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Addenbrookes Hospital
RECRUITINGCambridge, CB2 0QQ, United Kingdom
Contact Email: •••••@•••••
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Great Ormond Street Hospital
RECRUITINGLondon, WC1N 3JH, United Kingdom
Contact Email: •••••@•••••
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Hospital Universitari Vall Hebrón
RECRUITINGBarcelona, 08035, Spain
Contact Email: •••••@•••••
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Hospital Universitari i Politecnic La Fe
RECRUITINGValencia, 106046026, Spain
Contact Email: •••••@•••••
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Manchester Royal Infirmary, Manchester University NHS Foundation Trust,
RECRUITINGManchester, M13 9WL, United Kingdom
Contact Email: •••••@•••••
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University College London Hospitals NHS Foundation Trust
RECRUITINGLondon, NW1 2PG, United Kingdom
Contact Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.