New engineered immune cell therapy enters human testing for tough digestive cancers
NCT ID NCT05539430
Summary
This is an early-stage study testing the safety and optimal dose of a new treatment called LB1908, a type of CAR-T cell therapy, for adults with advanced cancers of the stomach, esophagus, or pancreas. The therapy involves collecting a patient's own immune cells, engineering them in a lab to target a specific protein (CLDN18.2) found on these cancer cells, and then infusing them back into the patient. The study will first find a safe dose and then see if the treatment shows early signs of helping control these difficult-to-treat cancers.
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Contacts and locations
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Locations
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Duke University
Durham, North Carolina, 27705, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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John Theurer Cancer Center at HackensackUMC
Hackensack, New Jersey, 07601, United States
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Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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OHSU Knight Cancer Institute
Portland, Oregon, 97239, United States
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States
Conditions
Explore the condition pages connected to this study.