New CAR t therapy targets Hard-to-Treat myeloma

NCT ID NCT06297226

Recruiting now Disease control Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment called arlocabtagene autoleucel (BMS-986393) for adults with multiple myeloma that has come back or not responded to other treatments. The therapy uses a patient's own immune cells, modified to attack cancer cells. The study aims to see if this treatment can shrink tumors and how safe it is. About 230 participants will take part.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Arthur J.E. Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Chiba University Hospital
RECRUITING

Chiba, 260-8677, Japan
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Hyogo Medical University Hospital
RECRUITING

Nishinomiya, Hyōgo, 663-8501, Japan
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Japanese Red Cross Medical Center
RECRUITING

Tokyo, 150-8935, Japan
LDS Hospital
RECRUITING

Salt Lake City, Utah, 84143, United States
Local Institution - 0065
WITHDRAWN

Baltimore, Maryland, 21218, United States
Local Institution - 0067
WITHDRAWN

Charlotte, North Carolina, 28204, United States
Local Institution - 0069
WITHDRAWN

Austin, Texas, 78704, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic in Rochester, Minnesota
RECRUITING

Rochester, Minnesota, 55905, United States
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Methodist HealthCare System of San Antonio Clinical Trials Office, Texas Transplant Institute
RECRUITING

San Antonio, Texas, 78229, United States
Miami Cancer Institute at Baptist Health, Inc.
RECRUITING

Miami, Florida, 33176, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Nagoya City University Hospital
RECRUITING

Nagoya, Aichi-ken, 467-8602, Japan
Northside Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Norton Women's and Children's Hospital
RECRUITING

Louisville, Kentucky, 40207, United States
Oncology Hematology Care
RECRUITING

Cincinnati, Ohio, 45242, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, Queensland, 4029, Australia
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sidney Kimmel Cancer Center - Jefferson Health
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
St Vincent's Hospital
RECRUITING

Melbourne, Victoria, 3065, Australia
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
The University of Kansas Cancer Center - Westwood
RECRUITING

Westwood, Kansas, 66205, United States
UCLA Hematology/Oncology - Westwood (Building 200 Suite 214)
RECRUITING

Los Angeles, California, 90095, United States
UCSF Helen Diller Medical Center at Parnassus Heights
RECRUITING

San Francisco, California, 94143, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University Hospital,Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, 602-8566, Japan
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294-3300, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of North Carolina Medical Center
RECRUITING

Chapel Hill, North Carolina, 27599-7305, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Winship Cancer Institute of Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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