Engineered immune cells take on tough lymphoma in new trial
NCT ID NCT07319676
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a personalized CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. Patients' own immune cells are collected, modified to target cancer cells, and infused back. The trial has two phases: first to find the safest dose, then to check how well it works in 30 participants aged 10 to 80.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CAR T-cells (Epo-R-CD19 CAR T with or without CD22 CAR T)
- What this could lead to
- If successful, this could offer a new treatment option for patients with hard-to-treat B-cell lymphoma, potentially leading to longer remission.
- What could go wrong
- This is an early-phase trial with only 30 participants, so results may not apply to everyone. There are risks of serious side effects like cytokine release syndrome (CRS) and neurological issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National University Hospital
RECRUITINGSingapore, Singapore, 119228, Singapore
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can immune cells plus a checkpoint drug outsmart lymphoma?
- Can an immune booster outsmart brain lymphoma?
- A shot at safer CAR t: early brain protection for lymphoma patients?
- Engineered immune cells take aim at Hard-to-Treat lymphomas
- Can donor immune cells be engineered to fight blood cancer?
- Can a simple blood test spot lymphoma earlier?