New hope for Tough-to-Treat breast cancer: major trial tests promising drug combo

NCT ID NCT03997123

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 study is testing whether adding the experimental drug capivasertib to standard paclitaxel chemotherapy works better than paclitaxel alone for advanced triple-negative breast cancer. It involves 923 patients with inoperable or spreading cancer who haven't had prior treatment for their advanced disease. The main goal is to see if the combination helps patients live longer and keeps the cancer from progressing.

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Contacts and locations

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Locations

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Whittier, California, 90602, United States
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Whittier, California, 90603, United States
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Fort Myers, Florida, 33901, United States
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Miami, Florida, 33136, United States
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St. Petersburg, Florida, 33705, United States
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Tampa, Florida, 33612, United States
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Chicago, Illinois, 60637, United States
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Westwood, Kansas, 66205, United States
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Silver Spring, Maryland, 20910, United States
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Detroit, Michigan, 48202, United States
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Nyack, New York, 10960, United States
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Cincinnati, Ohio, 45220, United States
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Columbus, Ohio, 43210, United States
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Harrisburg, Pennsylvania, 17109, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Nashville, Tennessee, 37203, United States
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Austin, Texas, 78758, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77090, United States
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San Antonio, Texas, 78229, United States
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Fairfax, Virginia, 22031, United States
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Buenos Aires, C1125ABD, Argentina
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CABA, 1414, Argentina
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CABA, C1012AAR, Argentina
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CABA, C1019ABS, Argentina
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CABA, C1426ANZ, Argentina
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Ciudad Autonomade Buenos Aires, 1426, Argentina
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La Plata, 1900, Argentina
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Mar del Plata, 7600, Argentina
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Rosario, 2000, Argentina
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Barretos, 14784-400, Brazil
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Florianópolis, 88034-000, Brazil
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Goiânia, 74605-070, Brazil
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Londrina, 86015-520, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90110-270, Brazil
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Porto Alegre, 90619-900, Brazil
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Rio de Janeiro, 20560-120, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01317-000, Brazil
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São Paulo, 04014-002, Brazil
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Victoria, British Columbia, V8R 6V5, Canada
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Kitchener, Ontario, N2G 1G3, Canada
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North York, Ontario, M2K 1E1, Canada
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Toronto, Ontario, M5G 1X5, Canada
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Beijing, 100021, China
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Beijing, China
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Changchun, 130021, China
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Changsha, 410013, China
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Changsha, 410078, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Foshan, 528000, China
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Guangzhou, 510060, China
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Guiyang, 550004, China
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Haikou, 570311, China
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Hangzhou, 310003, China
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Hangzhou, 310009, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230001, China
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Jinan, 250117, China
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Linyi, 276000, China
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Nanchang, 330009, China
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Nanjing, 210029, China
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Nanyang, 473009, China
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Shanghai, 200032, China
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Shenyang, 110001, China
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Shenyang, 110042, China
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Ürümqi, 830000, China
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Wenzhou, 325000, China
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Wuhan, 430030, China
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Wuhan, China
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Xi'an, 710061, China
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Zhengzhou, 450000, China
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Floridablanca, 681004, Colombia
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Ibagué, 730006, Colombia
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Medellín, 5001000, Colombia
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Montería, 23001, Colombia
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Valledupar, 200001, Colombia
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Hradec Králové, 500 05, Czechia
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Olomouc, 77900, Czechia
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Prague, 100 34, Czechia
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Prague, 128 08, Czechia
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Brest, 29609, France
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Lyon, 69008, France
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Marseille, 13009, France
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Montpellier, 34070, France
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Nice, 6189, France
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Paris, 75020, France
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Saint-Herblain, 44805, France
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Villejuif, 94805, France
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Athens, 115 22, Greece
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Athens, 11528, Greece
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Athens, 12462, Greece
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Heraklion, 71110, Greece
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Thessaloniki, 54645, Greece
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Budapest, 1062, Hungary
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Budapest, 1097, Hungary
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Budapest, 1106, Hungary
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Győr, 9024, Hungary
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Nyíregyháza, 4400, Hungary
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Szekszárd, 7100, Hungary
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Bangalore, 560052, India
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Bangalore, 560064, India
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Gūrgaon, 122001, India
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Kolkata, 700054, India
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Kolkata, 700160, India
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Mumbai, 400012, India
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Mysuru, 570017, India
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Nagpur, 440001, India
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Nagpur, 440012, India
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Nashik, 422002, India
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New Delhi, 110085, India
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New Delhi, 11029, India
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Bunkyō City, 113-8431, Japan
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Fukuoka, 811-1395, Japan
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Hidaka-shi, 350-1298, Japan
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Hiroshima, 730-8518, Japan
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Kagoshima, 892-0833, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Niigata, 951-8566, Japan
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Osaka, 540-0006, Japan
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Osaka, 541-8567, Japan
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Ota-shi, 373-8550, Japan
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Sapporo, 003-0804, Japan
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Sendai, 980-8574, Japan
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Shinagawa-ku, 142-8666, Japan
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Shinjuku-ku, 162-8655, Japan
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Sunto-gun, 411-8777, Japan
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Takasaki-shi, 370-0829, Japan
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Tsu, 514-8507, Japan
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Tsukuba, 305-8576, Japan
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Yokohama, 241-8515, Japan
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Kuala Lumpur, 50586, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Selangor, 62250, Malaysia
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Kuching, 93586, Malaysia
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Aguascalientes, 20230, Mexico
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Estado de México, 50080, Mexico
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Guadalajara, 44680, Mexico
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México, 06725, Mexico
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Monterrey, 64710, Mexico
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Tuxtla Gutiérrez, 29038, Mexico
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Tuxtla Gutiérrez, 29090, Mexico
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Arequipa, AREQUIPA01, Peru
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Callao, CALLAO 02, Peru
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Lima, 0051, Peru
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Lima, 15033, Peru
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Lima, L27, Peru
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Lima, LIMA 34, Peru
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Bacolod, 6100, Philippines
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Baguio City, 2600, Philippines
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Cagayan de Oro, 9000, Philippines
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Cebu City, 6000, Philippines
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Davao City, 8000, Philippines
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Iloilo City, 5000, Philippines
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Iloilo City, Philippines
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Las Piñas, 1740, Philippines
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Legaspi, 4500, Philippines
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Manila, 1000, Philippines
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Quezon City, 1112, Philippines
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San Juan City, 1500, Philippines
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Bydgoszcz, 85-796, Poland
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Konin, 62-500, Poland
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Poznan, 61-866, Poland
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Racibórz, 47-400, Poland
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Radom, 26-600, Poland
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Tomaszów Mazowiecki, 97-200, Poland
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Warsaw, 01-748, Poland
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Wroclaw, 53-413, Poland
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Lisbon, 1099-023, Portugal
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Lisbon, 1400-038, Portugal
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Lisbon, 1649-035, Portugal
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Porto, 4099-001, Portugal
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Arkhangelsk, 163045, Russia
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Moscow, 115478, Russia
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Moscow, 117997, Russia
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Moscow, 121205, Russia
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Moscow, 121467, Russia
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Saint Petersburg, 190103, Russia
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Saint Petersburg, 197758, Russia
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Volgograd, 400138, Russia
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Yaroslavl, 150054, Russia
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Dammam, 31444, Saudi Arabia
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Jeddah, 22384, Saudi Arabia
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Mecca, 24246, Saudi Arabia
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Riyadh, 11426, Saudi Arabia
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Riyadh, 11525, Saudi Arabia
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Riyadh, 12311, Saudi Arabia
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Riyadh, 12713, Saudi Arabia
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Bratislava, 833 01, Slovakia
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Johannesburg, 2193, South Africa
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Johannesburg, 2196, South Africa
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Pretoria, 0002, South Africa
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Pretoria, 0084, South Africa
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Busan, 602-739, South Korea
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Cheonan-si, 31151, South Korea
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Cheongju-si, 28644, South Korea
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Daegu, 41404, South Korea
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Goyang-si, 10408, South Korea
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Incheon, 21565, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 02841, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Badalona, 08916, Spain
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Barcelona, 08025, Spain
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Barcelona, 8035, Spain
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Hospitalet deLlobregat, 08907, Spain
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Jaén, 23007, Spain
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Madrid, 28046, Spain
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Málaga, 29010, Spain
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Seville, 41009, Spain
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Valencia, 46026, Spain
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Zaragoza, 50009, Spain
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Gothenburg, 413 45, Sweden
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Lund, 221 85, Sweden
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Stockholm, 118 83, Sweden
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Hsinchu, 300, Taiwan
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Hualien City, 97002, Taiwan
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Kaohsiung City, 82445, Taiwan
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Kaohsiung City, 83301, Taiwan
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Tainan, 710, Taiwan
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Tainan, 73657, Taiwan
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Taipei, 104, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 114, Taiwan
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Taipei, 235, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Hat Yai, 90110, Thailand
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Mueang, 50200, Thailand
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Ankara, 06100, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Malatya, 44280, Turkey (Türkiye)
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Mersin, 33070, Turkey (Türkiye)
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Edinburgh, EH4 2XU, United Kingdom
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London, E1 1BB, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE1 9RT, United Kingdom
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Sheffield, S10 2SJ, United Kingdom
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Surrey, GU2 7XX, United Kingdom
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York, YO31 8HE, United Kingdom
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, Vietnam

Conditions

Explore the condition pages connected to this study.

TRIPLE NEGATIVE BREAST NEOPLASMS