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Can cannabis alter sperm and testosterone? a trial seeks answers

NCT ID NCT06755346

Knowledge-focused Sponsor: Kanako Hayashi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This trial explores whether cannabis use changes male reproductive health, including sperm quality, testosterone levels, and genetic markers in sperm. Men who use cannabis regularly and those who don't will be randomly assigned to vape cannabis with different THC doses, a placebo, or no vaping. Researchers will measure sperm parameters, hormone levels, and stress responses to see if cannabis has a direct effect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cannabis (THC) in varying doses, including placebo
What this could lead to
If successful, this could clarify how cannabis affects male fertility, potentially informing guidance for men considering fatherhood.
What could go wrong
This is an early-phase trial with a small number of participants, so results may not apply broadly. Cannabis use may cause short-term side effects like anxiety or impaired coordination.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Expected to start

Apr 2025

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 64 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Regular cannabis users (21\~64 years-old men) who have used cannabis at least once a week for at least once a year or who have never used cannabis. * Willingness to abstain from using cannabis on the day of the testing session (minimum 5 hours abstinence). Exclusion Criteria: * Women * Adult men, 65 or older, and men under the age of 21 * Serious psychiatric conditions (e.g. psychosis, bipolar I and panic disorder) * Family history of psychosis * Chronic medical conditions (e.g., heart disease, diabetes) * History of adverse experiences with cannabis (e.g., anxiety and panic attacks) * Use of other illicit drugs (not cannabis) in the past 2 months * Heavy alcohol use (\>4 drinks, \>4 times/week) * Smoking/nicotine use * Infrequent cannabis use (less than once a week for only cannabis users) * BMI over 34 * Current use of corticosteroids and blood thinners

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Conditions

The condition(s) this trial relates to.

cannabis dependence male infertility male reproductive system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Male reproductive problem

Contacts and locations

Locations

  • Washington State University

    Pullman, Washington, 99164, United States